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  1. Molecular epidemiology of bartonella infections in patients with bacillary angiomatosis-peliosis.

    Article - En anglais

    Background Bacillary angiomatosis and bacillary peliosis are vascular proliferative manifestations of infection with species of the genus bartonella that oc-cur predominantly in patients infected with the hu-man immunodeficiency virus.

    Two species, Bartonella henselae and B. quintana, have been associated with bacillary angiomatosis, but culture and speciation are difficult, and there has been little systematic eval-uation of the species-specific disease characteristics.

    We studied 49 patients seen over eight years who were infected with bartonella species identified by molecular techniques and who had clinical lesions consistent with bacillary angiomatosis-peliosis.

    Methods In this case-control study, a standardized questionnaire about exposures was administered to patients with bacillary angiomatosis-peliosis and to 96 matched controls.

    The infecting bartonella species were determined by molecular techniques.

    Results Of the 49 patients with bacillary angi-omatosis-peliosis, 26 (53 percent) were infected with B. henselae and 23 (47 percent) with B. quinta-na.

    Subcutaneous and lytic bone lesions were strongly associated with B. quintana, whereas peliosis hepatis was associated exclusively with B. henselae.

    Patients with B.

    Henselae infection were identified throughout the study period and were epidemiolog-ically linked to cat and flea exposure (P¾0.004), whereas those with B. quintana were clustered and were characterized by low income (P=0.003), home-lessness (P=0.004).(...)

    Mots-clés Pascal : Angiomatose bacillaire, Péliose, Association, SIDA, Virose, Infection, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Etude cas témoin, Bartonella henselae, Bartonellaceae, Bactérie, Bartonella quintana, Evaluation, Facteur risque, Etude comparative, Questionnaire, Epidémiologie moléculaire, Homme, Etats Unis, Amérique du Nord, Amérique, Angiome, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Immunopathologie, Immunodéficit, Bactériose, Biologie moléculaire

    Mots-clés Pascal anglais : Bacillary angiomatosis, Peliosis, Association, AIDS, Viral disease, Infection, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Case control study, Bartonella henselae, Bartonellaceae, Bacteria, Bartonella quintana, Evaluation, Risk factor, Comparative study, Questionnaire, Molecular epidemiology, Human, United States, North America, America, Angioma, Cardiovascular disease, Vascular disease, Immunopathology, Immune deficiency, Bacteriosis, Molecular biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0054103

    Code Inist : 002B05B02L5. Création : 14/05/1998.