Does hepatitis GB virus-C infection cause hepatocellular carcinoma in black Africans ?
The newly cloned and characterized hepatitis GB virus-C (HGBV-C), which is the same virus as the independently discovered hepatitis G virus, has a global distribution, is transmitted parenterally, and causes chronic viremia.
The pathological consequences of infection with HGBV-C are uncertain, and its hepatocarcinogenic potential is unknown.
We used a case-control format to compare the prevalence of HGBV-C infection in 167 southern African blacks with hepatocellular carcinoma (HCC) and 167 race-age-and sex-matched hospital-based control subjects, and to test for possible interactive effects between this virus and hepatitis B and C viruses in the development of the tumor.
The presence of HGBV-C ribonucleic acid was detected in serum samples by reverse transcription, amplification of the resulting complementary deoxyribonucleic acid by the polymerase chain reaction (PCR), and Southern hybridization using a probe from the NS3/helicase region of the genome.
Serum samples were also tested for the presence of hepatitis B virus surface antigen, antibodies to hepatitis C virus, and hepatitis C virus ribonucleic acid.
Individuals infected with HGBV-C did not have an increased relative risk of developing HCC (relative risk 0.9 ; 95% confidence limits 0.5,1.7).
Moreover, co-infection with HGBV-C did not further increase the risk of tumor development in patients who were chronically infected with hepatitis B and/or C viruses. (...)
Mots-clés Pascal : Hépatite virale, Virose, Infection, Relation incertitude, Complication, Carcinome hépatocellulaire, Origine ethnique, Africain, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne, Virus hépatite GBV-C
Mots-clés Pascal anglais : Viral hepatitis, Viral disease, Infection, Uncertainty relation, Complication, Hepatocellular carcinoma, Ethnic origin, African, Epidemiology, Human, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0052519
Code Inist : 002B05C02G. Création : 14/05/1998.