Patterns of failure in differentiated carcinoma of the thyroid based on risk groups.
Annual Meeting of the American Association of Endocrine Surgeons. Napa Valley, CA, USA, 1996/04/21.
Risk-group stratification based on prognostic factors is well established in differentiated carcinoma of the thyroid gland.
Patients in the low-risk group have an excellent prognosis, whereas there is significant mortality associated with the high-risk group.
The purpose of this paper is to analyze the patterns of treatment failure in the various (local, regional, distant, and associated mortality) risk groups.
In a retrospective review of a consecutive series of 1038 previously untreated patients with differentiated carcinoma of the thyroid during a period of 55 years, various prognostic factors and risk groups were analyzed.
Significant prognostic factors were patient's age, presence of distant metastasis, extrathy-roid extension, size, and grade of the tumor.
Based on these factors, patients were divided into low- (39%), intermediate (39%), and high- (22%) risk groups.
The overall treatment-failure rates in the low-intermediate-and high-risk groups were 13%, 26%, and 50%, respectively, whereas the mortality rates in the same groups were 1%, 10%, and 33%, respectively.
The overall incidence of recurrence rate in the low-risk group is only 13%, compared with 50% in the high-risk group.
The incidence of distant metastasis in the low-risk group is only 2%, compared with 34% in the high-risk group. (...)
Mots-clés Pascal : Carcinome, Thyroïde, Cytodifférenciation, Rétrospective, Facteur risque, Traitement, Etiologie, Pronostic, Survie, Homme, Tumeur maligne, Endocrinopathie, Thyroïde pathologie
Mots-clés Pascal anglais : Carcinoma, Thyroid gland, Cell differentiation, Retrospective, Risk factor, Treatment, Etiology, Prognosis, Survival, Human, Malignant tumor, Endocrinopathy, Thyroid diseases
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0052222
Code Inist : 002B21C02. Création : 14/05/1998.