Impact of comorbidity on outcome of young patients with head and neck squamous cell carcinoma.
New York Head and Neck, Society, Preferred Paper Session. New York, NY, USA.
Comorbid conditions have a significant impact on the actuarial survival of patients with head and neck cancer.
However, no studies have evaluated the impact of comorbidity on tumor-and treatment-specific outcomes.
This study was performed to evaluate the impact of comorbidity, graded by the Kaplan-Feinstein comorbidity index (KFI) on the incidence and severity of complications, disease-free interval, and tumor-specific survival in patients undergoing curative treatment for head and neck cancer.
A multi-institutional, retrospective cohort of 70 patients 45 years of age and under with head and neck squamous cell carcinoma (SCC) presenting over an 11-year period was studied.
Advanced comorbidity (KFI grade 2 or 3) was present in 21 patients (30%). Patients with advanced comorbidity did not differ from patients with low-level comorbidity (KFI grades 0 or 1) in sex distribution, race, presence of human immunodeficiency virus (HIV) infection, tobacco use, location of primary lesion, stage at presentation, pathologic differentiation of the tumor, or type of initial treatment.
The overall incidence of treatment-associated complications was similar between the groups (57% versus 49% ; p>0.05), but a higher proportion of patients with advanced comorbidity developed high-grade complications (24% versus 6% ; p=04).
The median disease-free interval (11.1 months versus 21.6 months ; p=045) and tumor-specific survival (13.7 months versus 57. (...)
Mots-clés Pascal : Carcinome épidermoïde, Tête cou, Etude cohorte, Association morbide, Facteur impact, Complication, Classification par stade, Caractéristiques, Recherche scientifique, Evaluation, Adolescent, Homme, Tumeur maligne, ORL pathologie, Kaplan-Feinstein index
Mots-clés Pascal anglais : Squamous cell carcinoma, Head and neck, Cohort study, Concomitant disease, Impact factor, Complication, Stage classification, Characteristics, Scientific research, Evaluation, Adolescent, Human, Malignant tumor, ENT disease
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0052218
Code Inist : 002B10A01. Création : 14/05/1998.