To analyze the clinical features and to identify factors associated with the development of Raynaud's phenomenon (RP) in patients receiving chemotherapy for human immunodeficiency virus (HIV) related Kaposi's sarcoma.
A retrospective cohort study of all patients with Kaposi's sarcoma treated with chemotherapy at Toronto-Sunnybrook Regional Cancer Centre from 1987 to 1995.
Patients who developed RP were compared with those who did not with respect to age, CD4 cell count, Acquired Immune Deficiency Syndrome Clinical Trials Group (ACTG) stage, smoking history, type and dose of chemotherapy, and previous treatment with interferon and radiation therapy.
Eighty-seven patients with Kaposi's sarcoma were treated with chemotherapy between 1987 and 1995.
Five developed RP, which progressed to digital gangrene.
Median age, proportion of smokers, proportion defined as ACTG poor risk, median CD4 count, and history of opportunistic infections were equal in the 2 groups.
All patients with RP received vinblastine followed by bleomycin.
No cases of RP occurred in 27 patients treated with vinblastine alone or in 24 patients treated with bleomycin without previous vinblastine.
Patients developing RP tended to have received higher cumulative doses of chemotherapy including bleomycin (p=0.067) and previous treatment with either local radiation or interferon (p<0.009, p<0.001, respectively). (...)
Mots-clés Pascal : Kaposi maladie, Association, Homme, SIDA, Virose, Infection, Traitement, Chimiothérapie, Vinblastine, Bléomycine, Toxicité, Raynaud syndrome, Gangrène, Doigt, Epidémiologie, Facteur risque, Fréquence, Alcaloïde, Anticancéreux, Peau pathologie, Tumeur maligne, Immunopathologie, Immunodéficit, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Capillaire sanguin pathologie, Système nerveux autonome pathologie, Acrosyndrome
Mots-clés Pascal anglais : Kaposi sarcoma, Association, Human, AIDS, Viral disease, Infection, Treatment, Chemotherapy, Vinblastine, Bleomycin, Toxicity, Raynaud phenomenon, Gangrene, Finger, Epidemiology, Risk factor, Frequency, Alkaloid, Antineoplastic agent, Skin disease, Malignant tumor, Immunopathology, Immune deficiency, Cardiovascular disease, Vascular disease, Capillary vessel disease, Diseases of the autonomic nervous system, Acrosyndrome
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0048283
Code Inist : 002B02U03. Création : 14/05/1998.