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  1. Safe withdrawal of monotherapy for hypertension is poorly effective and not likely to reduce health-care costs.

    Article - En anglais

    Objective To carry out a population-based evaluation of withdrawal of treatment in primary care using repeated ambulatory blood pressure monitoring (ABPM) assessment to avoid subjecting patients to prolonged periods of excess risk Method Patients from two community practices (total population 11 034 patients) being administered monotherapy for hypertension, were identified and invited to participate.

    Subjects were withdrawn from treatment if they had no significant co-morbidity and daytime ABPM blood pressure was ¾ 150/90 mmHg.

    Antihypertensive therapy was restarted if daytime ABPM blood pressure was>150/90 mmHg during weeks 4,8,12,26,39 and 52.

    Results Of 126 eligible patients 53 had a co-morbidity and 37 declined to participate.

    Of the 36 patients who entered the study 10 were excluded because they had elevated ABPM blood pressures during treatment and one because they had echocardiographic left ventricular hypertrophy.

    Of the 25 patients from whom monotherapy was withdrawn, we restarted treatment of 19 before week 52.

    If clinic blood pressure monitoring had been used instead of ABPM, different decisions would have been taken in eight of 25 cases.

    The costs of the ABPM-determined withdrawal of treatment programme were greater than the expected savings in drug costs, even assuming that all six patients from whom treatment was withdrawn remained without treatment for a further 9 years. (...)

    Mots-clés Pascal : Hypertension artérielle, Antihypertenseur, Pression artérielle, Monitorage, Ambulatoire, Analyse coût efficacité, Economie santé, Chimiothérapie, Traitement, Arrêt traitement, Homme, Etude longitudinale, Appareil circulatoire pathologie

    Mots-clés Pascal anglais : Hypertension, Antihypertensive agent, Arterial pressure, Monitoring, Ambulatory, Cost efficiency analysis, Health economy, Chemotherapy, Treatment, Withdrawal, Human, Follow up study, Cardiovascular disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0047694

    Code Inist : 002B02F05. Création : 14/05/1998.