To study the relationship of brain natriuretic peptide concentrations to ageing, and whether brain natriuretic peptide could reflect current disease states in the general elderly population.
Brain natriuretic peptide was measured in two population samples from the general population.
Five hundred forty-five 85-year-old subjects from the longitudinal population study'70-year-old people in Gothenburg, Sweden'were investigated in respect to cardiovascular, renal and metabolic disease, and 191 subjects from the 40-year-old male population were examined.
To study the influence of ageing on circulating brain natriuretic peptide and the association between concentrations of brain natriuretic peptide and common disease states in the elderly.
Brain natriuretic peptide concentrations were significantly increased in relation to ageing (P<0.001).
Brain natriuretic peptide concentrations were significantly increased in elderly with congestive heart failure (P<0.001), ischaemic heart disease (P<0.001), atrial fibrillation (P<0.001) and renal dysfunction (P<0.001) but not in hypertension.
In multivariate analysis, brain natriuretic peptide concentrations were predictive for ischaemic heart disease (P<0.001), atrial fibrillation (P<0.01), renal dysfunction (P<0.01), congestive heart failure (P<0.05) and treatment with bêta-adrenergic blockers (P<0.05). (...)
Mots-clés Pascal : Peptide BNP, Concentration, Sang, Age, Appareil circulatoire pathologie, Etude comparative, Corrélation, Vieillard, Homme, Suède, Europe, Epidémiologie
Mots-clés Pascal anglais : Brain natriuretic peptide, Concentration, Blood, Age, Cardiovascular disease, Comparative study, Correlation, Elderly, Human, Sweden, Europe, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0043445
Code Inist : 002B12B06. Création : 17/04/1998.