Case-control study of oral contraceptives and risk of thromboembolic stroke : results from international study on oral contraceptives and health of young women.
To determine the influence of oral contraceptives (particularly those containing modern progestins) on the risk for ischaemic stroke in women aged 16-44 years.
Matched case-control study.
16 centres in the United Kingdom, Germany, France, Switzerland, and Austria.
Cases were 220 women aged 16-44 who had an incident ischaemic stroke.
Controls were 775 women (at least one hospital and one community control per case) unaffected by stroke who were matched with the corresponding case for 5 year age band and for hospital or community setting.
Information on exposure and confounding variables were collected in a face to face interview.
Main outcome measures
Odds ratios derived with stratified analyses and unconditional logistic regression to adjust for potential confounding.
Adjusted odds ratios (95% confidence intervals) for ischaemic stroke (unmatched analysis) were 4.4 (2.0 to 9.9), 3.4 (2.1 to 5.5), and 3.9 (2.3 to 6.6) for current use of first, second, and third generation oral contraceptives, respectively.
The risk ratio for third versus second generation was 1.1 (0.7 to 2.0) and was similar in the United Kingdom and other European countries.
The risk estimates were lower if blood pressure was checked before prescription. (...)
Mots-clés Pascal : Accident cérébrovasculaire, Thromboembolie, Contraception, Voie orale, Epidémiologie, Facteur risque, Toxicité, Adulte jeune, Homme, Femelle, Etude multicentrique, Europe, Etude cas témoin, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Cérébrovasculaire pathologie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie
Mots-clés Pascal anglais : Stroke, Thromboembolism, Contraception, Oral administration, Epidemiology, Risk factor, Toxicity, Young adult, Human, Female, Multicenter study, Europe, Case control study, Nervous system diseases, Central nervous system disease, Cerebral disorder, Cerebrovascular disease, Cardiovascular disease, Vascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0043435
Code Inist : 002B02U02. Création : 17/04/1998.