Social and biological predictors of early menopause : a model for premature aging.
To investigate possible social, lifestyle-related and biological predictors of early menopause in middle-aged women, followed prospectively for 11 years.
A prospective, population-based, cohort follow-up, observational study.
Glostrup Hospital, Copenhagen, Denmark.
A total of 493 female subjects, all aged 40 years at baseline, and divided into three groups according to self-reported menopausal age (40-45,46-51,51+years), after 12 months of amenorrhoea.
Women having had medical or surgical interventions to influence menopausal state were excluded.
Main outcome measures
Body mass index, glucose, insulin, lipids, creatinine, uric acid, thyroid-stimulating hormone (TSH), lung function tests (forced VC, FEV1, peak flow), blood pressure ; a self-administered questionnaire with questions on psychosocial variables, lifestyle, and self-rated health.
An early menopausal age correlated in an univariate way with impaired lung function, increased smoking habits and low social class (in childhood or present), as well as with a feeling of tiredness, all measured at the baseline investigation.
On the contrary, a later menopausal age correlated with higher serum insulin and uric acid levels.
In multiple regression analysis, with menopausal age as the dependent variable, it was found that smoking habits (number of years smoking) was inversely (P<0.001), and insulin as well as uric acid were positively. (...)
Mots-clés Pascal : Ménopause précoce, Statut socioéconomique, Catégorie socioprofessionnelle, Mode de vie, Tabagisme, Stress, Pronostic, Indicateur, Prédicteur, Homme, Femelle, Danemark, Europe, Etude comparative, Etude cohorte
Mots-clés Pascal anglais : Premature menopause, Socioeconomic status, Socioeconomic category, Life habit, Tobacco smoking, Stress, Prognosis, Indicator, Predictor, Human, Female, Denmark, Europe, Comparative study, Cohort study
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0042472
Code Inist : 002B20H. Création : 17/04/1998.