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  1. Social and biological predictors of early menopause : a model for premature aging.

    Article - En anglais

    Objectives

    To investigate possible social, lifestyle-related and biological predictors of early menopause in middle-aged women, followed prospectively for 11 years.

    Design

    A prospective, population-based, cohort follow-up, observational study.

    Setting

    Glostrup Hospital, Copenhagen, Denmark.

    Subjects

    A total of 493 female subjects, all aged 40 years at baseline, and divided into three groups according to self-reported menopausal age (40-45,46-51,51+years), after 12 months of amenorrhoea.

    Women having had medical or surgical interventions to influence menopausal state were excluded.

    Main outcome measures

    Body mass index, glucose, insulin, lipids, creatinine, uric acid, thyroid-stimulating hormone (TSH), lung function tests (forced VC, FEV1, peak flow), blood pressure ; a self-administered questionnaire with questions on psychosocial variables, lifestyle, and self-rated health.

    Results

    An early menopausal age correlated in an univariate way with impaired lung function, increased smoking habits and low social class (in childhood or present), as well as with a feeling of tiredness, all measured at the baseline investigation.

    On the contrary, a later menopausal age correlated with higher serum insulin and uric acid levels.

    In multiple regression analysis, with menopausal age as the dependent variable, it was found that smoking habits (number of years smoking) was inversely (P<0.001), and insulin as well as uric acid were positively. (...)

    Mots-clés Pascal : Ménopause précoce, Statut socioéconomique, Catégorie socioprofessionnelle, Mode de vie, Tabagisme, Stress, Pronostic, Indicateur, Prédicteur, Homme, Femelle, Danemark, Europe, Etude comparative, Etude cohorte

    Mots-clés Pascal anglais : Premature menopause, Socioeconomic status, Socioeconomic category, Life habit, Tobacco smoking, Stress, Prognosis, Indicator, Predictor, Human, Female, Denmark, Europe, Comparative study, Cohort study

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0042472

    Code Inist : 002B20H. Création : 17/04/1998.