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  1. Minimum effective dose of folic acid for food fortification to prevent neural-tube defects.

    Article - En anglais

    Background Although a daily supplement of 400 mug folic acid has been shown to prevent neural-tube defects (NTD), most women do not take the recommended supplement.

    Thus, food fortification is to be introduced in the USA and is being considered in the UK.

    Because of safety concerns, the USA has chosen a level of fortification that will increase the average woman's intake by only 100 mug.

    Such an increase, although safe, may be ineffective ; but a trial to assess its efficacy would be unethical.

    Because women with red-cell folate concentrations above 400 mug/L have a very low risk of NTD, we undertook a randomised trial of several folic acid doses to find out how much is needed to reach this protective concentration.

    Methods We screened 323 women.

    172 with red-cell folate between 150 mug/L and 400 mug/L were invited to take part in the trial. 121 women were randomly assigned placebo or 100 mug, 200 mug, or 400 mug daily of additional folic acid.

    Compliance was monitored by having the women sign a dated sheet when taking the tablet. 95 women completed the 6-month study.

    Findings There were significant increases in red-cell folate in all folic acid groups.

    The placebo group showed no significant change. (...)

    Mots-clés Pascal : Tube neural, Défaut, Prévention, Acide folique, Erythrocyte, Pharmacocinétique, Randomisation, Profilométrie, Etude comparative, Evaluation, Etats Unis, Amérique du Nord, Amérique, Homme, Femelle, Système nerveux pathologie, Vitamine

    Mots-clés Pascal anglais : Neural tube, Defect, Prevention, Folic acid, Red blood cell, Pharmacokinetics, Randomization, Profilometry, Comparative study, Evaluation, United States, North America, America, Human, Female, Nervous system diseases, Vitamin

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0042262

    Code Inist : 002B02B11. Création : 17/04/1998.