The influence of the infecting virus genotype on the progression of the underlying liver disease in patients with chronic hepatitis C virus (HCV) infection remains controversial.
The aim of this study was to investigate the prevalence of HCV genotypes in Spanish patients with chronic HCV infection and to elucidate the relationship between the infecting genotype and the severity of the disease.
A cross-sectional, retrospective analysis of frequency distribution of HCV genotypes was carried out in 414 Spanish patients with chronic HCV infection, including 243 patients with asymptomatic or minimally symptomatic chronic hepatitis, 112 patients with cirrhosis and hepatocellular carcinoma and 59 patients with decompensated cirrhosis.
HCV genotype was determined by restriction fragment length poly-morphisms of the 5'non-coding region.
Infection with HCV genotype 1b was found in 72% of patients with chronic hepatitis and in more than 90% of patients with cirrhosis, with or without hepatocellular carcinoma.
Older age, infection with genotype 1b and absence of overt parenteral exposure as a possible source of infection were associated with cirrhosis and hepatocellular carcinoma by univariate analysis and this association was confirmed by regression analysis.
HCV genotype 1b is associated with advanced liver disease in our geographical area. (...)
Mots-clés Pascal : Hépatite virale C, Virose, Infection, Exploration, Génotype, Virus hépatite C, Hepacivirus, Flaviviridae, Virus, Relation incertitude, Evolution, Carcinome hépatocellulaire, Cirrhose, Epidémiologie, Homme, Espagne, Europe, Appareil digestif pathologie, Foie pathologie, Tumeur maligne
Mots-clés Pascal anglais : Viral hepatitis C, Viral disease, Infection, Exploration, Genotype, Hepatitis C virus, Hepacivirus, Flaviviridae, Virus, Uncertainty relation, Evolution, Hepatocellular carcinoma, Cirrhosis, Epidemiology, Human, Spain, Europe, Digestive diseases, Hepatic disease, Malignant tumor
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0041712
Code Inist : 002B05C02G. Création : 17/04/1998.