Elevated homocysteine increases the risk of vascular disease, in particular amongst younger subjects (<60 years).
Very few studies have been performed amongst older subjects.
We evaluated the relation of plasma total homocysteine (tHcy) to atherosclerosis and symptomatic cardiovascular disease amongst older men and women.
A cross-sectional study.
A random sample of 630 men and women, participating in the Rotterdam Study, a prospective population-based cohort study amongst 7983 subjects aged 55 years and over residing in the Ommoord district of Rotterdam, the Netherlands.
Carotid atherosclerosis (carotid plaques and common carotid intima-media thickness) assessed by ultrasonography ; lower extremity (peripheral) artery atherosclerosis measured by the ratio of the ankle to arm systolic blood pressure ; prevalent cardiovascular disease assessed as a history of myocardial infarction or stroke.
Subjects, 55-74 years of age, with elevated tHcy levels (=18.6 mumol L-1) had a thicker common carotid intima-media (difference 0.037 mm ; 95% CI 0.001,0.073), a lower ankle-arm index (-0.054 ; - 0.104, - 0.004), and an increased risk of cardiovascular disease (odds ratio 3.0 ; 1.5,6.1), after adjusting for sex and age.
There was no appreciable association of tHcy levels to atherosclerosis and cardiovascular disease in subjects aged 75 years and older. (...)
Mots-clés Pascal : Appareil circulatoire pathologie, Athérosclérose, Homocystéine, Epidémiologie, Facteur risque, Vieillard, Homme, Pays Bas, Europe
Mots-clés Pascal anglais : Cardiovascular disease, Atherosclerosis, Epidemiology, Risk factor, Elderly, Human, Netherlands, Europe
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0041499
Code Inist : 002B30A01A2. Création : 17/04/1998.