Occupational exposure to gasoline has been identified in several studies as a risk factor for renal-cell cancer.
Cases of renal-cell cancer with and without work-related exposure to gasoline or gasoline and diesel fuel were studied for the presence of mutations in the tumour-suppressor gene p53 (n=23 exposed and 30 non-exposed cases studied) and ras oncogene (n=30 exposed and 36 non-exposed cases studied).
An average cumulative exposure was estimated at 10 ppm-years benzene among the exposed.
Three p53 mutations were detected by denaturing-gradient gel electrophoresis (DGGE) among the 23 exposed cases (3/23,13%). Of the non-exposed referent cases, 4 had a mutation (4130,13%). All but one of the cases with a p53 mutation had smoked.
A ras gene (K-ras or N-ras) mutation was found in 3 (3/66,4.5%) cases, all of whom were smoker referents.
We conclude that p53 and ras mutations are infrequent in renal-cell cancer associated with occupational exposure to gasoline.
However, the majority of the mutations (617 for p53, and 3/3 for ras genes) were seen in smokers.
Mots-clés Pascal : Hypernéphrome, Essence, Exposition professionnelle, Mutation, Protooncogène, Gène onc cellulaire, Gène suppresseur tumeur, Gène TP53, Facteur risque, Epidémiologie, Finlande, Europe, Carcinome, Rein, Appareil urinaire pathologie, Rein pathologie, Tumeur maligne, Médecine travail, Maladie professionnelle, Génétique, Gène ras
Mots-clés Pascal anglais : Grawitz tumor, Gasoline, Occupational exposure, Mutation, Protooncogene, C-Onc gene, Tumor suppressor gene, TP53 Gene, Risk factor, Epidemiology, Finland, Europe, Carcinoma, Kidney, Urinary system disease, Kidney disease, Malignant tumor, Occupational medicine, Occupational disease, Genetics
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0038691
Code Inist : 002B14D01. Création : 17/04/1998.