Clinical and epidemiological studies have given discordant results on the usefulness of the level of circulating elastin peptide (EP), a potential marker of both elastin destruction (a key phenomenon in pulmonary emphysema) and neosynthesis, for assessing structural changes in the lung extracellular matrix.
The aim of the present study was to explore the relationship between levels of EP and forced expiratory volume in one second (FEV1) and single breath transfer factor for carbon monoxide (TLCO and KCO) in coal miners.
The study population comprised 227 working coal miners aged 34-50 years consisting of 75 miners heavily exposed to underground coal dust with pulmonary radiographs classified as 0/1 or 110 by the International Labour Office classification, 75 exposed miners with radiographs classified as normal (010), and 77 miners slightly exposed to coal dust with normal radiographs.
The subjects answered a standardised questionnaire and performed spirometric tests and a carbon monoxide (CO) transfer test.
No association was observed between EP levels and% predicted FEV1 (or FEV1/FVC).
The level of EP increased significantly with decreased% predicted TLCO (r=-0.20).
Miners in the lowest% predicted Kco quintile had higher EP levels than the rest (3.28 (1.37) vs 2.47 (1.16)). (...)
Mots-clés Pascal : Emphysème, Poumon, Elastine, Sérum, VEMS, Facteur transfert, Carbone monoxyde, France, Europe, Mineur, Charbon, Médecine travail, Pathogénie, Epidémiologie, Homme, Appareil respiratoire pathologie, Poumon pathologie
Mots-clés Pascal anglais : Emphysema, Lung, Elastin, Serum, Maximal expiratory volume per second, Transfer factor, Carbon monoxide, France, Europe, Minor, Coal, Occupational medicine, Pathogenesis, Epidemiology, Human, Respiratory disease, Lung disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0038543
Code Inist : 002B11D. Création : 17/04/1998.