Two years after the October 1995 pill scare that received worldwide attention, this synthesis of evidence goes back to the earliest research on risks of first generation oral contraceptives (OCs).
It also covers epidemiological data published since, emphasising the 1995-1996 findings.
Late breaking data are also examined.
The key issue : are there differences in the risk profiles of second and third generation OCs.
The ultimate question is : did any epidemics of venous thromboembolism (VTE) occur ?
This synthesis of evidence leads to the following conclusions and observations :
(i) all OCs on the market are becoming progressively safer ;
(ii) relative risks of about 2 for VTE, even if real, are clinically unimportant and of no public health significance ;
(iii) the weak odds ratios contrasting third and second generation OCs, ranging from 1.5 to 2. (...)
Mots-clés Pascal : Contraceptif, Voie orale, Toxicité, Facteur risque, Thromboembolie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Femelle, Epidémiologie
Mots-clés Pascal anglais : Contraceptive, Oral administration, Toxicity, Risk factor, Thromboembolism, Cardiovascular disease, Vascular disease, Female, Epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0034953
Code Inist : 002B02P. Création : 17/04/1998.