Seldom in the history of medicine has an entire generation of patients with an incurable, progressive, and ultimately fatal disease suddenly been offered the prospect of extended survival and even, perhaps, a « second life. » The relatively simultaneous appearance of 2 major treatment developments has created profound changes in therapeutic options and outlook.
The first development is an assay of serum levels of human immunodeficiency virus viral copies, providing a critical tool for clinical decision making.
The second is the marketing between December 1995 and April 1997 of 4 human immunodeficiency virus protease inhibitors that, combined with previously available antiviral medications, achieve a new level of efficacy.
With the advent of these changes come multiple psychiatric research and policy issues.
These include the development of strategies to establish and maintain medication adherence.
This is a critical task, given the complexity of combination therapy regimens and the rapid onset of viral resistance to protease inhibitors within days to weeks of missed or suboptimal dosing.
The psychological issues to be studied include the process of restructuring lives and expectations in the event of clinical benefit or managing the distress associated with clinical failure. (...)
Mots-clés Pascal : SIDA, Virose, Infection, Chimiothérapie, Traitement, Inhibiteur enzyme, Peptidases, Hydrolases, Enzyme, Antiviral, Coping, Observance médicamenteuse, Observance thérapeutique, Expectation, Prise risque, Trouble psychiatrique, Interaction médicamenteuse, Psychotrope, Accessibilité, Soin, Article synthèse, Homme, Immunopathologie, Immunodéficit
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Chemotherapy, Treatment, Enzyme inhibitor, Peptidases, Hydrolases, Enzyme, Antiviral, Coping, Drug compliance, Treatment compliance, Expectation, Risk taking, Mental disorder, Drug interaction, Psychotropic, Accessibility, Care, Review, Human, Immunopathology, Immune deficiency
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0031765
Code Inist : 002B05C02D. Création : 17/04/1998.