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  1. Fulltext. A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer.

    Article - En anglais


    Polymorphisms in the N-acetyltransferase 2 (NAT2) gene are determinants of the rate of metabolic activation of carcinogenic compounds such as aryl aromatic amines.

    Homozygosity for any combination of three variant alleles in Caucasians defines'slow'acetylators ; presence of one or two wild-type alleles characterizes'rapid'acetylators.

    Although most previous studies have not observed an overall elevation in risk of breast cancer among slow acetylators, a recent study observed that cigarette smoking was associated with a large increase in risk of breast cancer among slow acetylators.

    We assessed the relation between NAT2 acetylation status and breast cancer risk, and its interaction with smoking, in a prospective study of mainly Caucasian US women.

    Four hundred and sixty-six incident cases who were diagnosed with breast cancer after giving a blood specimen in 1989-90 were matched to 466 controls in a nested case-control study.

    NAT2 genotype was determined using PCR-RFLP assays.

    The multivariate relative risk (RR) comparing slow with rapid acetylators was 0.9 (95% CI0.7-1.2).

    Among slow acetylators, current smoking immediately prior to diagnosis was not associated with a significant elevation in risk compared with never smoking rapid acetylators (RR=1.4,95% CI 0.7-2.6).

    No significant association was seen between pack-years of smoking and risk of breast cancer among either slow or fast acetylators. (...)

    Mots-clés Pascal : Phénotype acétylateur, Epidémiologie, Facteur risque, Tabagisme, Tumeur maligne, Glande mammaire, Homme, Femelle, Caucasoïde, Etats Unis, Amérique du Nord, Amérique, Génétique, Glande mammaire pathologie, Gène NAT2

    Mots-clés Pascal anglais : Acetylator phenotype, Epidemiology, Risk factor, Tobacco smoking, Malignant tumor, Mammary gland, Human, Female, Caucasoid, United States, North America, America, Genetics, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0030243

    Code Inist : 002B20E02. Création : 17/04/1998.