logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Fulltext. A prospective study of NAT2 acetylation genotype, cigarette smoking, and risk of breast cancer.

    Article - En anglais

    Fulltext.

    Polymorphisms in the N-acetyltransferase 2 (NAT2) gene are determinants of the rate of metabolic activation of carcinogenic compounds such as aryl aromatic amines.

    Homozygosity for any combination of three variant alleles in Caucasians defines'slow'acetylators ; presence of one or two wild-type alleles characterizes'rapid'acetylators.

    Although most previous studies have not observed an overall elevation in risk of breast cancer among slow acetylators, a recent study observed that cigarette smoking was associated with a large increase in risk of breast cancer among slow acetylators.

    We assessed the relation between NAT2 acetylation status and breast cancer risk, and its interaction with smoking, in a prospective study of mainly Caucasian US women.

    Four hundred and sixty-six incident cases who were diagnosed with breast cancer after giving a blood specimen in 1989-90 were matched to 466 controls in a nested case-control study.

    NAT2 genotype was determined using PCR-RFLP assays.

    The multivariate relative risk (RR) comparing slow with rapid acetylators was 0.9 (95% CI0.7-1.2).

    Among slow acetylators, current smoking immediately prior to diagnosis was not associated with a significant elevation in risk compared with never smoking rapid acetylators (RR=1.4,95% CI 0.7-2.6).

    No significant association was seen between pack-years of smoking and risk of breast cancer among either slow or fast acetylators. (...)

    Mots-clés Pascal : Phénotype acétylateur, Epidémiologie, Facteur risque, Tabagisme, Tumeur maligne, Glande mammaire, Homme, Femelle, Caucasoïde, Etats Unis, Amérique du Nord, Amérique, Génétique, Glande mammaire pathologie, Gène NAT2

    Mots-clés Pascal anglais : Acetylator phenotype, Epidemiology, Risk factor, Tobacco smoking, Malignant tumor, Mammary gland, Human, Female, Caucasoid, United States, North America, America, Genetics, Mammary gland diseases

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0030243

    Code Inist : 002B20E02. Création : 17/04/1998.