Polymorphisms in the N-acetyltransferase 2 (NAT2) gene are determinants of the rate of metabolic activation of carcinogenic compounds such as aryl aromatic amines.
Homozygosity for any combination of three variant alleles in Caucasians defines'slow'acetylators ; presence of one or two wild-type alleles characterizes'rapid'acetylators.
Although most previous studies have not observed an overall elevation in risk of breast cancer among slow acetylators, a recent study observed that cigarette smoking was associated with a large increase in risk of breast cancer among slow acetylators.
We assessed the relation between NAT2 acetylation status and breast cancer risk, and its interaction with smoking, in a prospective study of mainly Caucasian US women.
Four hundred and sixty-six incident cases who were diagnosed with breast cancer after giving a blood specimen in 1989-90 were matched to 466 controls in a nested case-control study.
NAT2 genotype was determined using PCR-RFLP assays.
The multivariate relative risk (RR) comparing slow with rapid acetylators was 0.9 (95% CI0.7-1.2).
Among slow acetylators, current smoking immediately prior to diagnosis was not associated with a significant elevation in risk compared with never smoking rapid acetylators (RR=1.4,95% CI 0.7-2.6).
No significant association was seen between pack-years of smoking and risk of breast cancer among either slow or fast acetylators. (...)
Mots-clés Pascal : Phénotype acétylateur, Epidémiologie, Facteur risque, Tabagisme, Tumeur maligne, Glande mammaire, Homme, Femelle, Caucasoïde, Etats Unis, Amérique du Nord, Amérique, Génétique, Glande mammaire pathologie, Gène NAT2
Mots-clés Pascal anglais : Acetylator phenotype, Epidemiology, Risk factor, Tobacco smoking, Malignant tumor, Mammary gland, Human, Female, Caucasoid, United States, North America, America, Genetics, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0030243
Code Inist : 002B20E02. Création : 17/04/1998.