This report is part of a larger, multicenter, placebo-controlled study designed to test the effects of low and high salt intake on the antihypertensive action of enalapril maleate or isradipine in salt-sensitive, hypertensive patients.
To present our findings with respect to the effects of race, age, sex, and weight on the blood pressure response to low and high salt intake in salt-sensitive hypertensive patients before randomization into the larger study.
After 3 weeks (weeks - 9 to - 6) of ad lib salt intake (100-200 mmol/d of sodium), 1916 patients whose sitting diastolic blood pressure was between 95 and 115 mm Hg entered a 3-week period (week - 6 to - 3) of low salt intake (50-80 mmol/d of sodium) and then a 3-week period (week - 3 to 0) of high salt intake (200-250 mmol/d of sodium).
Of the 1916 patients, 624 were identified as being sensitive to salt by demonstrating an increase in sitting diastolic blood pressure of equal to or more than 5 mm Hg from the low to high salt intake.
Of these patients, 367 were white, 156 were black, 92 were Hispanic, 8 were Asian, and 1 was American Indian.
Also, 315 were men and 309, women ; 351 were 55 years or younger and 273 were older than 55 years ; and 195 had a body mass index of 27 or less and 429 had a body mass index higher than 27.
The sitting blood pressure decreased with salt restriction and increased with salt load in all groups of patients (P<. 001). (...)
Mots-clés Pascal : Hypertension artérielle, Etude multicentrique, Facteur risque, Sel, Etiologie, Race, Fonction poids, Sexe, Critère âge, Evaluation, Homme, Appareil circulatoire pathologie, Activité biologique, Métabolisme pathologie, Education santé
Mots-clés Pascal anglais : Hypertension, Multicenter study, Risk factor, Salt, Etiology, Race, Weight function, Sex, Age criterion, Evaluation, Human, Cardiovascular disease, Biological activity, Metabolic diseases, Health education
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0028323
Code Inist : 002B12B05B. Création : 17/04/1998.