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  1. There are no racial, age, sex, or weight differences in the effect of salt on blood pressure in salt-sensitive hypertensive patients.

    Article - En anglais

    Background 

    This report is part of a larger, multicenter, placebo-controlled study designed to test the effects of low and high salt intake on the antihypertensive action of enalapril maleate or isradipine in salt-sensitive, hypertensive patients.

    Objective 

    To present our findings with respect to the effects of race, age, sex, and weight on the blood pressure response to low and high salt intake in salt-sensitive hypertensive patients before randomization into the larger study.

    Patients and Methods 

    After 3 weeks (weeks - 9 to - 6) of ad lib salt intake (100-200 mmol/d of sodium), 1916 patients whose sitting diastolic blood pressure was between 95 and 115 mm Hg entered a 3-week period (week - 6 to - 3) of low salt intake (50-80 mmol/d of sodium) and then a 3-week period (week - 3 to 0) of high salt intake (200-250 mmol/d of sodium).

    Of the 1916 patients, 624 were identified as being sensitive to salt by demonstrating an increase in sitting diastolic blood pressure of equal to or more than 5 mm Hg from the low to high salt intake.

    Of these patients, 367 were white, 156 were black, 92 were Hispanic, 8 were Asian, and 1 was American Indian.

    Also, 315 were men and 309, women ; 351 were 55 years or younger and 273 were older than 55 years ; and 195 had a body mass index of 27 or less and 429 had a body mass index higher than 27.

    Results 

    The sitting blood pressure decreased with salt restriction and increased with salt load in all groups of patients (P<. 001). (...)

    Mots-clés Pascal : Hypertension artérielle, Etude multicentrique, Facteur risque, Sel, Etiologie, Race, Fonction poids, Sexe, Critère âge, Evaluation, Homme, Appareil circulatoire pathologie, Activité biologique, Métabolisme pathologie, Education santé

    Mots-clés Pascal anglais : Hypertension, Multicenter study, Risk factor, Salt, Etiology, Race, Weight function, Sex, Age criterion, Evaluation, Human, Cardiovascular disease, Biological activity, Metabolic diseases, Health education

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0028323

    Code Inist : 002B12B05B. Création : 17/04/1998.