Cederholm T, Arner P, Palmblad J (Karolinska Institute at the Centre for Inflammation & Hematology Research, and Huddinge University Hospital, Huddinge, Sweden).
Low circulating leptin levels in protein-energy malnourished chronically ill elderly patients.
To evaluate serum leptin, a fat cell-derived protein, levels in relation to the malnutrition often observed in chronic disease.
A comparison of circulating leptin concentrations in malnourished chronically ill elderly and in age-matched controls.
A university-affiliated teaching hospital in Stockholm, Sweden.
Nineteen protein-energy malnourished elderly patients (74 ± 1 years) with various chronic nonmalignant diseases and 18 healthy controls (72 ± 1 years).
Serum leptin levels measured by radioimmunoassay technique, nutritional status as expressed by body mass index (kg m-), triceps skin fold, arm muscle circumference and serum albumin, and serum orosomucoid concentrations indicating inflammatory status.
Patients and controls displayed body mass indexes of 17.4 ± 0.7 and 25. ± 1.1 (P<0.001), respectively.
Triceps skin fold (TSF) measurements revealed a pronounced fat depletion in the patients, being 8.5 ± 0.9 and 22.3 ± 1.5 mm (P<0.001) in female and 6.1 ± 0.7 and 10.8 ± 0.8 mm (P<0.001) in male patients and controls, respectively.
Patient serum leptin concentrations were less than half of the corresponding concentrations in the controls, 4.3 ± 1. (...)
Mots-clés Pascal : Malnutrition, Vieillard, Homme, Epidémiologie, Leptine, Etude comparative, Critère âge, Méthode radioimmunologique, Inflammation, Evaluation, Trouble nutrition, Activité biologique
Mots-clés Pascal anglais : Malnutrition, Elderly, Human, Epidemiology, Leptin, Comparative study, Age criterion, Radioimmunoassay, Inflammation, Evaluation, Nutrition disorder, Biological activity
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0028163
Code Inist : 002B02N. Création : 17/04/1998.