Genetics and developmental psychopathology : 1. Phenotypic assessment in the Virginia twin study of adolescent behavioral development.
We introduce an overlapping cohort sequential longitudinal study of behavioral development and psychopathology in a representative sample of 1412 pairs of twins aged 8 through 16 years.
Multiple phenotypic assessments involve a full psychiatric interview with each child and each parent, and supplementary parental, teacher, and child interview material and questionnaires.
For the first wave of assessments, the numbers of reported DSM-III-R symptoms of Major Depressive Disorder (MDD), Separation Anxiety Disorder (SAD), Overanxious Disorder (OAD), Oppositional Defiant Disorder (ODD), Conduct Disorder (CD), and Attention Deficit Hyperactivity Disorder (ADHD), assessed through interviews, confirm patterns of age and sex trends found in other epidemiological samples, but underscore their dependence on whether the child or the parent is the informant.
Correlations across domains for symptoms reported by the same informant are often as large as correlations across informants for the same domain of symptoms.
Factor analyses of these symptom counts, taking account ofinformant view and unreliability of assessment, show the high degree of correlation between SAD and OAD, between MDD and OAD, and between CD and ODD.
ADHD symptoms are relatively independent of the other domains, but show moderate correlations with CD, ODD, and MDD. (...)
Mots-clés Pascal : Etat dépressif, Trouble anxieux, Trouble conduite, Trouble attention, Hyperactivité, Trouble psychiatrique, Déterminisme génétique, Phénotype, Epidémiologie, Etude longitudinale, Développement, Age scolaire, Enfant, Homme, Préadolescent, Adolescent, Sexe, Jumeau monozygote, Jumeau dizygote, Trouble humeur, Trouble comportement social, Informant
Mots-clés Pascal anglais : Depression, Anxiety disorder, Conduct disorder, Attentional disorder, Hyperactivity, Mental disorder, Genetic determinism, Phenotype, Epidemiology, Follow up study, Development, School age, Child, Human, Preadolescent, Adolescent, Sex, Monozygotic twin, Dizygotic twin, Mood disorder, Social behavior disorder
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0028105
Code Inist : 002B18D10. Création : 17/04/1998.