Genetic influences on alcoholism risk are well-documented in men, but uncertain in women.
We tested for gender differences in genetic influences on, and risk-factors for, DSM-III-R alcohol dependence (AD).
Diagnostic follow-up interviews were conducted in 1992-3 by telephone with twins from an Australian twin panel first surveyed in 1980-82 (N=5889 respondents).
Data were analysed using logistic regression models.
Significantly higher twin pair concordances were observed in MZ compared to DZ same-sex twin pairs in women and men, even when data were weighted to adjust for over-representation of well-educated respondents, and for selective attrition.
AD risk was increased in younger birth cohorts, in Catholic males or women reporting no religious affiliation, in those reporting a history of conduct disorder or major depression and in those with high Neuroticism, Social Nonconformity, Toughmindedness, Novelty-Seeking or (in women only) Extraversion scores ; and decreased in'Other Protestants'weekly church attenders, and university-educated males.
Controlling for these variables, however, did not remove the significant association with having an alcoholic MZ co-twin, implying that much of the genetic influence on AD risk remained unexplained.
No significant gender difference in the genetic variance in AD was found (64% heritability, 95% confidence interval 32-73%). (...)
Mots-clés Pascal : Dépendance, Boisson alcoolisée, Alcoolisme, Facteur risque, Etude familiale, Jumeau monozygote, Jumeau dizygote, Génétique, Sexe, Génétique épidémiologique, Homme
Mots-clés Pascal anglais : Dependence, Alcoholic beverage, Alcoholism, Risk factor, Family study, Monozygotic twin, Dizygotic twin, Genetics, Sex, Epidemiologic genetics, Human
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0027414
Code Inist : 002B18C05B. Création : 17/04/1998.