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  1. Does transplantation produce quality of life benefits ? A quantitative analysis of the literature.

    Article - En anglais


    Despite numerous reports published since the early 1970s, it is frequently asserted that quality of life (QOL) outcomes of transplantation have seldom been investigated and/or that little is known about QOL.

    This view may have persisted due to lack of adequate cumulation and synthesis of existing data.

    We performed an exhaustive, quantitative literature review to determine the nature and degree of any QOL benefits associated with transplantation in adults.


    All independent, peer-reviewed empirical, English-language QOL studies were retrieved for six areas of transplantation : kidney, pancreas/combined kidney-pancreas, heart, lung/combined heart-lung, liver, and bone marrow.

    Studies'findings were analyzed to determine whether the weight of evidence suggested that (a) QOL improved from pre-to posttransplant, (b) transplant recipient QOL was better than that of patient comparison groups, and (c) recipient QOL equaled that of healthy nonpatient samples.


    A total of 218 independent studies, evaluating a total of approximately 14,750 patients, were identified.

    The majority of studies demonstrated statistically significant (P<0.05) pre-to posttransplant improvements in physical functional QOL, mental It health/cognitive status, social functioning, and overall QOL perceptions.

    The majority documented physical functional and global QOL advantages for transplant recipients relative to ill comparison groups. (...)

    Mots-clés Pascal : Transplantation, Epidémiologie, Etude comparative, Qualité vie, Critère sélection, Evaluation, Revue bibliographique, Article synthèse, Homme, Facteur efficacité, Chirurgie

    Mots-clés Pascal anglais : Transplantation, Epidemiology, Comparative study, Quality of life, Selection criterion, Evaluation, Bibliographic review, Review, Human, Effectiveness factor, Surgery

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0026546

    Code Inist : 002B25N. Création : 17/04/1998.