Chemical degradation of wastes of antineoplastic agents : 2 : Six anthracyclines : Idarubicin, doxorubicin, epirubicin, pirarubicin, aclarubicin, and daunorubicin.
Object : Handling of genotoxic compounds commonly used in cancer chemotherapy generates contaminated wastes that require decontamination before disposal.
Chemical methods are an alternative and/or a complement to incineration for the treatment of wastes and spills.
As part of a program initiated by the International Agency for Research on Cancer (IARC), 3 chemical methods readily available in the hospital environment - sodium hypochlorite (NaOCI, 5.25%), hydrogen peroxide (H2O2, ¾30%) and Fenton reagent (FeCl2,2H2O ; 0.3 g in 10 ml H2O2,30%) - are being tested for the degradation of a total of 32 antineoplastic agents.
The efficiency of degradation was monitored by high-pressure liquid chromatography.
The mutagenicity of the degradation residues were tested by the Ames test using tester strains Salmonella typhimurium TA 97a, TA 98, TA 100, and TA 102 with and without an exogenous metabolic activation system.
The first results obtained for the degradation of cyclophosphamide, ifosfamide, and melphalan have been published in this journal.
The present manuscript reports the results of the investigation of a series of six anthracyclines (aclarubicin, daunorubicin, doxorubicin, epirubicin, idarubicin. and pirarubicin) commonly used in chemotherapy treatment.
Pharmaceutical preparations corresponding to the most concentrated administration solutions in either NaCI. (...)
Mots-clés Pascal : Anticancéreux, Déchet hospitalier, Médicament, Décontamination, Traitement déchet, Anthracyclines, Dégradation chimique, Sodium Hypochlorite, Elimination déchet, Test mutagénicité, Toxicité
Mots-clés Pascal anglais : Antineoplastic agent, Hospital waste, Drug, Decontamination, Waste treatment, Anthracyclins, Chemical degradation, Sodium Hypochlorites, Waste elimination, Mutagenicity testing, Toxicity
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0026115
Code Inist : 002B30A02A. Création : 17/04/1998.