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  1. Cost analysis of the introduction of PBPC for autologous transplantation : effect of switching from bone marrow (BM) to peripheral blood progenitor cells (PBPC).

    Article - En anglais

    Increasingly, PBPC instead of BM are used for autologous transplantation.

    Limited data exist on the economic effects of this change.

    Using a resource-based utilization model we prospectively determined the costs of 48 autologous transplants (eight BM, 17 BM+PBPC, 23 PBPC), isolating the post-reinfusion period (day 0 to discharge) to better determine the effect of the rescue product.

    Length of stay post-reinfusion was significantly shorter in patients receiving PBPC (median 13 days) or BM+PBPC (median 14 days) vs BM alone (median 20 days) (P<0.01).

    Accordingly, transplant admission costs were less in the PBPC groups (PBPC $22089, BM+PBPC $23179) vs the BM alone group ($32289) (P<0.05).

    Rescue product acquisition costs were higher for PBPC (range $3439-$5157) vs BM ($2766) but these costs were offset by the more rapid recovery of patients receiving PBPC.

    Overall transplant costs depend on the conditioning regimen with a 10-fold cost variation among regimens.

    Modeled costs for autologus transplantation using various approaches to rescue product acquisition are given.

    The introduction of PBPC for autologus transplantation has resulted in cost savings at our institution.

    Although the acquisition costs of PBPC rescue product are greater than for BM, this incremental expense is more than offset by a less expensive post-reinfusion period.

    Mots-clés Pascal : Hémopathie maligne, Autogreffe, Greffe, Cellule souche, Cellule hématopoïétique, Sang, Analyse coût, Moelle osseuse, Etude comparative, Economie santé, Canada, Amérique du Nord, Amérique, Homme, Transfusion

    Mots-clés Pascal anglais : Malignant hemopathy, Autograft, Graft, Stem cell, Hematopoietic cell, Blood, Cost analysis, Bone marrow, Comparative study, Health economy, Canada, North America, America, Human, Transfusion

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0019631

    Code Inist : 002B27D02. Création : 17/04/1998.