Context. - Breast cancer is a major cause of mortality among women.
It is important to identify modifiable risk factors for this disease.
- To examine body mass index (BMI) at the age of 18 years and at midlife and adult weight change in relation to breast cancer incidence and mortality.
- Cohort study.
- A cohort of 95 256 US female nurses aged 30 to 55 years who were followed up for 16 years.
- Incident and fatal breast cancer.
- During 1 203 498 person-years, 2517 incident breast cancers (60% postmenopausal) were documented.
Higher current BMI was associated with lower breast cancer incidence before menopause and was minimally associated with incidence after menopause.
However, a stronger positive relationship was seen among postmenopausal women who never used hormone replacement (relative risk=1.59 for BMI>31 kg/m2 vs ¾20 kg/m2 ; 95% confidence interval, 1.09-2.32 ; P for trend<. 001).
Higher BMI at the age of 18 years was associated with lower breast cancer incidence both before and after menopause.
Weight gain after the age of 18 years was unrelated to breast cancer incidence before menopause, but was positively associated with incidence after menopause.
This increased risk with weight gain was limited to women who never used postmenopausal hormones ; among these women, the relative risk was 1.99 (95% confidence interval, 1.43-2.76) for weight gain of more than 20 kg vs unchanged weight. (...)
Mots-clés Pascal : Tumeur maligne, Glande mammaire, Poids corporel, Prise poids, Indice masse corporelle, Postménopause, Préménopause, Ménopause, Facteur risque, Homme, Femelle, Etude cohorte, Glande mammaire pathologie
Mots-clés Pascal anglais : Malignant tumor, Mammary gland, Body weight, Weight gain, Body mass index, Postmenopause, Premenopause, Menopause, Risk factor, Human, Female, Cohort study, Mammary gland diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0019124
Code Inist : 002B20E02. Création : 17/04/1998.