To assess the frequency and characteristics of hilar and mediastinal involvement in patients with Wegener's granulomatosis (WG).
A patient with WG presented with the unusual finding of a mediastinal mass, prompting a comprehensive review of 302 patient records from 2 WG registries to obtain evidence of hilar adenopathy or mediastinal masses.
Clinic progress notes and findings of chest imaging studies (routine imaging and computed tomography) were reviewed for the presence of hilar lymphadenopathy, mediastinal masses, or mediastinal lymphadenopathy.
All radiographs and surgical pathology specimens from these lesions were reviewed.
Six examples of mediastinal or hilar involvement (2.0%) were identified among 302 patients with WG.
Three of these 6 patients had mediastinal masses.
One patient with a mediastinal mass also had mediastinal lymphadenopathy.
Two of the patients with mediastinal masses had lung parenchymal lesions.
The remaining 3 patients had enlarged hilar lymph nodes in addition to pulmonary parenchymal lesions.
All of the patients were treated with corticosteroids and cytotoxic drugs.
Followup information was available on all patients.
In the remaining 4 patients, the mediastinal mass or hilar lymphadenopathy decreased in size or resolved after 2 months of immunosuppressive therapy.
Mots-clés Pascal : Granulomatose Wegener, Homme, Complication, Epidémiologie, Fréquence, Symptomatologie, Médiastin pathologie, Masse, Diagnostic, Adénopathie, Hile pulmonaire, Traitement, Thorax, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Vascularite, Maladie système, Poumon pathologie, Lymphatique pathologie
Mots-clés Pascal anglais : Wegener granulomatosis, Human, Complication, Epidemiology, Frequency, Symptomatology, Mediastinum disease, Mass, Diagnosis, Adenopathy, Hilus of the lung, Treatment, Thorax, Cardiovascular disease, Vascular disease, Vasculitis, Systemic disease, Lung disease, Lymphatic vessel disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0018134
Code Inist : 002B07. Création : 17/04/1998.