To determine the extent of significant osteopenia in prepubertal patients with juvenile rheumatoid arthritis (JRA) not treated with corticosteroids and to identify variables that are highly related to bone mineralization in this population.
In a cross-sectional study, 48 JRA patients and 25 healthy control subjects ages 4.6-11.0 years were evaluated.
Total body bone mineral density (TB BMD) was determined by Hologic dual energy x-ray absorptiometry.
All patients were prepubertal (Tanner stage I or II) and had never taken corticosteroids.
For comparison, JRA patients were divided into « low » TB BMD (Z score<-1) or « normal » TB BMD (Z score Results.
The overall mean ± SD TB BMD scores did not differ between the JRA subjects (0.75 ± 0.06 gm/cm2) and controls (0.73 ± 0.07 gm/cm2 ; P>0.30).
However, 29.2% of the JRA patients had low TB BMD, whereas only 16% would be expected to have low TB BMD based on the standard normal distribution (goodness of fit X2=4.84, P=0.01).
The mean Z score for the JRA patients with low TB BMD was - 1.43, and for those with normal TB BMD, it was 0.32. (...)
Mots-clés Pascal : Arthrite chronique juvénile, Enfant, Homme, Prépuberté, Spectrométrie absorption RX, Densité, Os, Epidémiologie, Exploration, Facteur prédictif, Ostéopénie, Croissance, Corps entier, Chronique, Système ostéoarticulaire pathologie, Rhumatisme inflammatoire, Exploration radiologique, Ostéopathie, Double énergie
Mots-clés Pascal anglais : Juvenile rheumatoid arthritis, Child, Human, Prepuberty, X ray absorption spectrometry, Density, Bone, Epidemiology, Exploration, Predictive factor, Osteopenia, Growth, Whole body, Chronic, Diseases of the osteoarticular system, Inflammatory joint disease, Radiologic investigation, Bone disease, Dual energy
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0018128
Code Inist : 002B15D. Création : 17/04/1998.