To determine whether there is an independent association between Helicobacter pylori infection of the stomach and ischaemic heart disease.
Design-Prospective study with measurement of IgG antibody titres specific to H pylori on stored serum samples from 648 men who died from ischaemic heart disease and 1296 age matched controls who did not (nested case-control design).
Subjects-21 520 professional men aged 35-64 who attended the British United Provident Association (BUPA) medical centre in London between 1975 and 1982 for routine medical examination.
Main outcome measure-Death from ischaemic heart disease.
The odds of death from ischaemic heart disease in men with H pylori infection relative to that in men without infection was 1.06 (95% confidence interval 0.86 to 1.31).
In a separate group of 206 people attending the centre, plasma fibrinogen was virtually the same in those who were positive for H pylori (2.62 g/l) and those who were negative (2.64 g/l).
Conclusions-A study that by its size and design minimised both random error and socioeconomic bias found no relation between H pylori infection and ischaemic heart disease.
The validity of the study was shown by its confirmation of the recognised association between H pylori infection and stomach cancer (odds ratio 4.0 (1.9 to 8.2) ; P<0.001). (...)
Mots-clés Pascal : Infarctus, Myocarde, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Infection, Estomac, Sérologie, Mortalité, Epidémiologie, Facteur risque, Homme, Royaume Uni, Europe, Prospective, Appareil circulatoire pathologie, Cardiopathie coronaire, Myocarde pathologie, Estomac pathologie, Appareil digestif pathologie
Mots-clés Pascal anglais : Infarct, Myocardium, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Infection, Stomach, Serology, Mortality, Epidemiology, Risk factor, Human, United Kingdom, Europe, Prospective, Cardiovascular disease, Coronary heart disease, Myocardial disease, Gastric disease, Digestive diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0018033
Code Inist : 002B12A03. Création : 17/04/1998.