Efficacy trials of antihelminthic therapies conducted in Africa have reported improvements in children's growth, but nutritional evaluations of large-scale deworming programs are lacking.
We evaluated the first-year effect on growth of a school-based deworming program in Zanzibar, where growth retardation occurs in school children.
Children in four primary schools were given thrice-yearly mebendazole (500 mg) and compared with children in four schools that received twice-yearly mebendazole and children in four non-program schools.
Evaluation schools were randomly selected and allocated to control, twice-yearly or thrice-yearly deworming.
Approximately 1000 children in each program group completed the 1 - y follow-up.
Children<10 y old gained 0.27 kg more weight (P<0.05) and 0.13 cm more height (P=0.20) in the twice-yearly group, and 0.20 kg more weight (P=0.07) and 0.30 cm more height (P<0.01) in the thrice-yearly group, compared with the control group.
Children<10 y old with higher heights-for-age at baseline had higher weight and height gains in response to deworming.
In children = 10 y old, overall program effects on height or weight gains were not significant.
But in this age range, younger boys had significant improvements in height gain with thrice-yearly deworming, and children with higher heights-for-age had greater improvements in weight gain with deworming. (...)
Mots-clés Pascal : Traitement, Anthelminthique, Développement staturopondéral, Ecole, Antiparasitaire, Programme sanitaire, Enfant, Homme, Politique sanitaire, Zanzibar, Tanzanie, Afrique
Mots-clés Pascal anglais : Treatment, Anthelmintic, Somatic growth, School, Parasiticid, Sanitary program, Child, Human, Health policy, Zanzibar, Tanzania, Africa
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0013231
Code Inist : 002B30A03B. Création : 17/04/1998.