Gene deletion at the glutathione S-transferase mu locus (GSTMI) has previously been associated with increased risk for environmentally-induced cancers (e.g. smoking-related lung cancer).
In the present study we examined the hypothesis that GSTMI deletion is a risk factor for malignant brain tumors in adults.
We compared the prevalence of the GSTMI homozygous deletion polymorphism in 158 Caucasian adults with gliomas with 157 controls.
Cases and controls were drawn from a large population-based case-control study of brain cancers in six San Francisco Bay area counties.
Overall, the prevalence of the GSTM1 deletion was similar in cases (83/158 ; 53%) and controls (78/157 ; 50%). Among brain tumor cases, analysis of variance modeling indicated a significant interaction of GSTMI genotype and gender associated with age at diagnosis (P=0.02).
This effect was due to the fact that women with GSTMI deletion were younger on average at diagnosis than women who were GSTMI positive (43.9 years versus 52.4 years, respectively).
Age at diagnosis among men was similar for those who were GSTMI deleted and GSTM1 positive (49.4 years and 47.2 years, respectively).
The younger age at diagnosis of GSTMI null female cases compared with GSTMI positive cases was observed in astrocytoma as well as the higher grade tumors (e.g. glioblastoma multiforme).
There was no association of GSTMI deletion with age or gender in controls. (...)
Mots-clés Pascal : Délétion, Gène, Glutathione transferase, Transferases, Enzyme, Gliome, Facteur risque, Tumeur maligne, Intracrânien, Homme, Prévalence, Polymorphisme, Génétique, Interaction génotype environnement, Caucasoïde, Etiologie, Aberration chromosomique, Chromosome anormal, Tumeur, Système nerveux pathologie, Système nerveux central pathologie, Encéphale pathologie, Epidémiologie moléculaire
Mots-clés Pascal anglais : Deletion, Gene, Glutathione transferase, Transferases, Enzyme, Glioma, Risk factor, Malignant tumor, Intracranial, Human, Prevalence, Polymorphism, Genetics, Genotype environment interaction, Caucasoid, Etiology, Chromosomal aberration, Abnormal chromosome, Tumor, Nervous system diseases, Central nervous system disease, Cerebral disorder, Molecular epidemiology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0009399
Code Inist : 002B17E. Création : 17/04/1998.