To study the efficacy of pneumococcal capsular polysaccharide vaccine among the elderly by use of a population-based intervention in one township, Varkaus, Eastern Finland.
A randomized, controlled trial in which elderly inhabitants (aged 60 years or older) of the catchment area were randomized to receive either pneumococcal and influenza vaccines (PI group=vaccinated) or influenza vaccine alone (I group=controls) and offered participation.
The response rate was 67.4%. The PI group consisted of 1,364 persons and the I group of 1,473 persons.
The vaccinations were performed in the municipal health center in the fall of 1982, and all elderly inhabitants were followed for 3 years for the development of radiologically confirmed pneumonia.
Pneumococcal etiology was identified by serological methods.
The incidence of pneumonia was 18.8 per 1,000 person-years in the PI group (73 pneumonia episodes) and 16.6 per 1,000 person-years in the I group (69 episodes).
Pneumococcal etiology was found in 27 episodes in the Pl group (incidence 7.0 per 1,000 person-years) and in 36 episodes in the I group (incidence 8.6 per 1,000 person-years).
In controls (I group) the incidence of pneumococcal pneumonia was significantly higher among persons with increased risk for contracting pneumonia (19 per 1,000 person-years) than among controls with low risk status (4 per 1,000 person-years). (...)
Mots-clés Pascal : Vaccination, Streptococcus pneumoniae, Streptococcaceae, Micrococcales, Bactérie, Prévention, Efficacité, Essai clinique, Vieillard, Homme, Finlande, Europe, Randomisation
Mots-clés Pascal anglais : Vaccination, Streptococcus pneumoniae, Streptococcaceae, Micrococcales, Bacteria, Prevention, Efficiency, Clinical trial, Elderly, Human, Finland, Europe, Randomization
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0006791
Code Inist : 002B05A02. Création : 17/04/1998.