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  1. Clinical efficacy of pneumococcal vaccine in the elderly : A randomized, single-blind population-based trial.

    Article - En anglais


    To study the efficacy of pneumococcal capsular polysaccharide vaccine among the elderly by use of a population-based intervention in one township, Varkaus, Eastern Finland.


    A randomized, controlled trial in which elderly inhabitants (aged 60 years or older) of the catchment area were randomized to receive either pneumococcal and influenza vaccines (PI group=vaccinated) or influenza vaccine alone (I group=controls) and offered participation.

    The response rate was 67.4%. The PI group consisted of 1,364 persons and the I group of 1,473 persons.

    The vaccinations were performed in the municipal health center in the fall of 1982, and all elderly inhabitants were followed for 3 years for the development of radiologically confirmed pneumonia.

    Pneumococcal etiology was identified by serological methods.


    The incidence of pneumonia was 18.8 per 1,000 person-years in the PI group (73 pneumonia episodes) and 16.6 per 1,000 person-years in the I group (69 episodes).

    Pneumococcal etiology was found in 27 episodes in the Pl group (incidence 7.0 per 1,000 person-years) and in 36 episodes in the I group (incidence 8.6 per 1,000 person-years).

    In controls (I group) the incidence of pneumococcal pneumonia was significantly higher among persons with increased risk for contracting pneumonia (19 per 1,000 person-years) than among controls with low risk status (4 per 1,000 person-years). (...)

    Mots-clés Pascal : Vaccination, Streptococcus pneumoniae, Streptococcaceae, Micrococcales, Bactérie, Prévention, Efficacité, Essai clinique, Vieillard, Homme, Finlande, Europe, Randomisation

    Mots-clés Pascal anglais : Vaccination, Streptococcus pneumoniae, Streptococcaceae, Micrococcales, Bacteria, Prevention, Efficiency, Clinical trial, Elderly, Human, Finland, Europe, Randomization

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0006791

    Code Inist : 002B05A02. Création : 17/04/1998.