Objectives-To investigate risk of lung cancers associated with common established carcinogenic occupational exposures (asbestos, paint dust, polycyclic aromatic hydrocarbons, and welding fumes) in a prospective cohort study among the general population, and to estimate the proportion of lung cancer cases attributable to these occupational exposures.
Methods-A prospective cohort study on diet, other lifestyle factors, job history, and cancer risk that started in 1986 in The Netherlands on 58 279 men, aged 55-69 years.
Based on information about job history obtained from a self administered questionnaire, case by case expert assessment was carried out to assign to each study subject a cumulative probability of occupational exposure for each carcinogenic exposure.
For analysis, a case-cohort approach was used, in which the person-years at risk were estimated from a randomly selected subcohort (n=1688).
After 4.3 years of follow up, 524 lung cancer cases with complete job history were available.
After adjustment for age, each of the other occupational exposures, and for smoking habits and intake of vitamin C, bêta-carotene, and retinol, significant associations were found between risk of lung cancer and cumulative probability of exposure to asbestos (relative risk (RR) highest/no exposure=3.49,95% confidence interval (95% CI) 1.69 to 7.18, trend P<0.01) or paint dust (RR highest/no exposure=2.48,95% CI 0.88 to 6.97, trend P<0.01). (...)
Mots-clés Pascal : Carcinogène, Composé chimique, Exposition professionnelle, Tumeur maligne, Bronchopulmonaire, Médecine travail, Amiante, Poussière, Peinture, Etude cohorte, Pays Bas, Europe, Epidémiologie, Appareil respiratoire pathologie, Poumon pathologie, Bronche pathologie
Mots-clés Pascal anglais : Carcinogen, Chemical compound, Occupational exposure, Malignant tumor, Bronchopulmonary, Occupational medicine, Asbestos, Dust, Paint, Cohort study, Netherlands, Europe, Epidemiology, Respiratory disease, Lung disease, Bronchus disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0006445
Code Inist : 002B11A. Création : 17/04/1998.