To compare risk factors for HIV seropositivity with risk factors for HIV seroconversion in a population of volunteer blood donors in Harare, Zimbabwe, and to assess the impact of risk factor exclusion strategies on the safety of the blood supply.
A secondary analysis of a longitudinal cohort study was performed.
The subjects were volunteer blood donors who were also taking part in a prospective cohort study in Harare, Zimbabwe.
They were tested for HIV antibodies upon enrollment and at 6-month intervals.
Their donation history, age, marital status and the presence or absence of multiple sex partners and paying for sex were assessed as predictors of HIV seropositivity and HIV seroconversion.
The impact of exclusion strategies on blood safety was modeled by estimating the number of HIV-infected units that would escape detection by antibody screening if blood donors with these risk factors were excluded.
The HIV seroprevalence among persons accepted for blood donation was 8.8% ; the HIV seroincidence was 2.1 per 100 person-years.
Significant risk factors for HIV seropositivity were being a new donor (odds ratio 7.3,95% confidence interval 4.4-12.1), age over 25 years (odds ratio 1.6, confidence interval 1.1-2.4), being married (odds ratio 1.7, confidence interval 1.2-2.6), paying for sex (odds ratio 2.6, confidence interval 1.7-3.9) and multiple sex partners (odds ratio 2.1, confidence interval 1.4-2.9). (...)
Mots-clés Pascal : SIDA, Virose, Infection, Prévalence, Sérologie, Incidence, Etude comparative, Analyse risque, Facteur risque, Homme, Donneur sang, Zimbabwe, Afrique, Transfusion, Sang, Dépistage, Virus immunodéficience humaine, Lentivirus, Retroviridae, Virus, Immunopathologie, Immunodéficit, Prévention
Mots-clés Pascal anglais : AIDS, Viral disease, Infection, Prevalence, Serology, Incidence, Comparative study, Risk analysis, Risk factor, Human, Blood donor, Zimbabwe, Africa, Transfusion, Blood, Medical screening, Human immunodeficiency virus, Lentivirus, Retroviridae, Virus, Immunopathology, Immune deficiency, Prevention
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0005734
Code Inist : 002B05C02D. Création : 17/04/1998.