Assessment of liver cirrhosis severity in 1015 patients of the Euricterus database with Campbell-Child, Pugh-Child and with ascites and Ascites-Nutritional State (ANS) related classifications.
The assessment of disease stage in cirrhosis is important for the individual patient (prognosis, timing and risk for requiring surgical intervention) and also for population comparisons and trials.
There are several established methods, and we have aimed at comparison of the methods within a large cirrhosis population.
In the European Union Euricterus database, there are 1015 patients with a « certain » diagnosis of cirrhosis, each of whom in one session had a protocol work-up of history, physical examination and all laboratory investigations needed for this study.
The Child-Turcotte (CT), Campbell-Child (C) and Pugh-Child (P) classifications, as well as ascites/no ascites, ascites 1,2,3 (no, therapy responsive, nonresponsive) and ascites/nutritional state (ANS, 1-9) scores were used.
CT and C have the same 5 variables, P has prothrombin time instead of nutritional state.
CT, C and P variables score 1-3 each.
C and P furthermore have variable range scores of 5-15.
CT, C and P have classes A-C.
The variables used were ascites, nutritional state, encephalopathy, bilirubin, albumin and prothrombin time.
Only 53 patients (5%) fit within the CT criteria.
C and P variable range scores (5-15) correlated strongly (r=0.84).
Cross-over calculation showed slightly different results in the P and C choice of variables, while the variable ranges (1-3) did not matter. (...)
Mots-clés Pascal : Cirrhose, Foie, Evaluation, Indice gravité, Echelle évaluation, Complication, Ascite, Stade clinique, Etat nutritionnel, Corrélation, Homme, Appareil digestif pathologie, Foie pathologie, Abdomen pathologie, Epanchement
Mots-clés Pascal anglais : Cirrhosis, Liver, Evaluation, Severity score, Evaluation scale, Complication, Ascites, Clinical stage, Nutritional status, Correlation, Human, Digestive diseases, Hepatic disease, Abdominal disease, Effusion
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0005712
Code Inist : 002B13C03. Création : 17/04/1998.