With advances in molecular genetic technology, more studies will examine gene-environment interaction in disease etiology.
If the primary purpose of the study is to estimate the effect of gene-environment interaction in disease etiology, one can do so without employing controls.
The case-only design has been promoted as an efficient and valid method for screening for gene-environment interaction.
The authors derive a method for estimating sample size requirements, present sample size estimates, and compare minimum sample size requirements to detect gene-environment interaction in case-only studies with case-control studies.
Assuming independence between exposure and genotype in the population, the authors believe that the case-only design is more efficient than a case-control design in detecting gene-environment interaction.
They also illustrate a method to estimate sample size when information on marginal effects (relative risk) of exposure and genotype is available from previous studies.
Mots-clés Pascal : Epidémiologie, Méthodologie, Interaction génotype environnement, Taille échantillon, Homme, Etiologie, Génétique, Biologie moléculaire
Mots-clés Pascal anglais : Epidemiology, Methodology, Genotype environment interaction, Sample size, Human, Etiology, Genetics, Molecular biology
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0005377
Code Inist : 002B30A01A1. Création : 17/04/1998.