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  1. Fulltext. Sample size requirements in case-only designs to detect gene-environment interaction.

    Article - En anglais


    With advances in molecular genetic technology, more studies will examine gene-environment interaction in disease etiology.

    If the primary purpose of the study is to estimate the effect of gene-environment interaction in disease etiology, one can do so without employing controls.

    The case-only design has been promoted as an efficient and valid method for screening for gene-environment interaction.

    The authors derive a method for estimating sample size requirements, present sample size estimates, and compare minimum sample size requirements to detect gene-environment interaction in case-only studies with case-control studies.

    Assuming independence between exposure and genotype in the population, the authors believe that the case-only design is more efficient than a case-control design in detecting gene-environment interaction.

    They also illustrate a method to estimate sample size when information on marginal effects (relative risk) of exposure and genotype is available from previous studies.

    Mots-clés Pascal : Epidémiologie, Méthodologie, Interaction génotype environnement, Taille échantillon, Homme, Etiologie, Génétique, Biologie moléculaire

    Mots-clés Pascal anglais : Epidemiology, Methodology, Genotype environment interaction, Sample size, Human, Etiology, Genetics, Molecular biology

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0005377

    Code Inist : 002B30A01A1. Création : 17/04/1998.