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  1. Epidemiological characteristics and risk factors of hepatocellular carcinoma : Molecular biology, pathogenesis and clinics.

    Article, Communication - En anglais

    International Symposium on Hepatology. Taipei (TWN), 1996/11/30.

    Hepatocellular carcinoma (HCC) is one of the major cancers in the world.

    There is a striking variation in HCC incidence rates between various countries, with a highest-to-lowest ratio of 112.5 for males and 54.7 for females.

    The high-risk populations are clustered in sub-Saharan Africa and eastern Asia.

    The male-to-female ratio for HCC ranges from<1 to 6.4 and mostly from 2 to 4. There exist significant variations in the incidence of HCC among different ethnic groups living in the same area and among migrants of the same ethnic groups living in different areas.

    The age curves of HCC are significantly different in various countries, suggesting variability in exposure to risk factors.

    Chronic carriers of hepatitis B and C viruses (HBV and HCV, respectively) have an increased risk of HCC.

    The relative and attributable HCC risk of HBV and HCV carrier status varies in different countries.

    There exists a synergistic interaction on HCC between the two viruses.

    Aflatoxin exposure, cigarette smoking, heavy alcohol consumption, low vegetable intake, inorganic arsenic ingestion, radioactive thorium dioxide exposure, iron overload and the use of oral contraceptives and anabolic steroids have been documented as HCC risk factors.

    Recent molecular epidemiological studies have shown that low serum retinol levels as well as elevated serum levels of testosterone, neu oncoprotein and aflatoxin Bl-albumin adduct are associated with an increased HCC risk. (...)

    Mots-clés Pascal : Carcinome hépatocellulaire, Incidence, Prédisposition, Influence, Sexe, Origine ethnique, Facteur risque, Etiologie, Pathogénie, Epidémiologie, Homme, Appareil digestif pathologie, Foie pathologie, Tumeur maligne

    Mots-clés Pascal anglais : Hepatocellular carcinoma, Incidence, Predisposition, Influence, Sex, Ethnic origin, Risk factor, Etiology, Pathogenesis, Epidemiology, Human, Digestive diseases, Hepatic disease, Malignant tumor

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0003710

    Code Inist : 002B13C01. Création : 17/04/1998.