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  1. Prospective screening of dyspeptic patients by Helicobacter pylori serology : A safe policy ?

    Article - En anglais

    Background and Study Aims 

    Endoscopic screening of all dyspeptic patients is not cost-effective, nor is it feasible in many health-care delivery systems.

    To select the most appropriate candidates, various preendoscopic screening strategies have been proposed, some of which include Helicobacter pylori serology and patient age.

    We assessed the value of these two criteria in preendoscopic screening of a large series of dyspeptic patients, and compared the results obtained in a referral hospital (university center with an extensive H. pylori research program) with those in nonreferral hospitals (participating centers that did not have such a program).

    Patients and Methods 

    Blood samples for determination of anti-H. pylori IgG antibody were collected from patients with uninvestigated dyspepsia undergoing endoscopy at one referral hospital and in 93 nonreferral hospitals throughout Italy.

    For IgG antibody assay, an in-house enzyme-linked immunosorbent assay (ELISA) technique was used in the referral hospital, while a commercial kit was used in the nonreferral hospitals.


    A total of 1638 patients were evaluated at the referral hospital (845 men and 793 women, mean age 46.1 years, range 18-89), and 3281 at the nonreferral hospitals (1718 men and 1563 women, mean age 48.8, range 18-96), respectively.

    If endoscopy had not been performed in patients who were seronegative for H. pylori and younger than 45 years, 19% versus 17. (...)

    Mots-clés Pascal : Dyspepsie, Chronique, Indication, Gastroscopie, Critère décision, Séropositivité, Gastrite, Campylobactériose, Bactériose, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bactérie, Etude statistique, Homme, Appareil digestif pathologie, Endoscopie, Estomac pathologie

    Mots-clés Pascal anglais : Dyspepsia, Chronic, Indication, Gastroscopy, Decision criterion, Seropositivity, Gastritis, Campylobacter infection, Bacteriosis, Infection, Helicobacter pylori, Spirillaceae, Spirillales, Bacteria, Statistical study, Human, Digestive diseases, Endoscopy, Gastric disease

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 98-0003282

    Code Inist : 002B24E06. Création : 17/04/1998.