Extrahepatic portal vein obstruction has been shown to cause growth retardation in children, though literature is scant.
No information is available regarding the cause of growth retardation in these patients.
To document the presence of growth retardation in this disease, we studied growth and nutrition in 33 consecutive prepubertal patients.
Anthropometry, fasting growth hormone, and insulin-like growth factor I levels were compared in 22 well-nourished patients from this group with 35 age-matched well-nourished controls.
Mean ± SD height standard deviation score of well-nourished patients (-1.88 ± 1.33) was significantly below that of the controls (-1.06 ± 0.64, p<0.01).
Patients also had significantly lower midarm muscle circumference z scores (-2.65 ± 1.09) than controls (-1.17 ± 1.09, p<0.0001), though triceps skinfold thickness z scores were comparable in the two groups (-1.60 ± 0.68 vs - 1.24 ± 0.79, p=NS).
Insulin-like growth factor I z scores were significantly lower in patients (-1.48 ± 0.88) than in controls (-0.49 ± 1.09, p<0.001), whereas basal growth hormone was significantly higher in patients (4.60 ± 3.70 mIU/L) compared with controls (2.66 ± 0.82, p<0.01).
Extrahepatic portal vein obstruction in children leads to growth retardation.
Anthropometric and preliminary hormonal evaluation suggest resistance to the action of growth hormone as a possible mechanism.
Mots-clés Pascal : Veine porte, Obstruction, Facteur risque, Retard staturopondéral, Etude comparative, STH, Anthropométrie, Prospective, Evaluation, Facteur croissance IGF1, Enfant, Homme, Inde, Asie, Appareil circulatoire pathologie, Vaisseau sanguin pathologie, Métabolisme pathologie, Obstruction veine portale extrahepatique (EHPVO)
Mots-clés Pascal anglais : Portal vein, Obstruction, Risk factor, Growth retardation, Comparative study, STH, Anthropometry, Prospective, Evaluation, Insulin like growth factor 1, Child, Human, India, Asia, Cardiovascular disease, Vascular disease, Metabolic diseases
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0002192
Code Inist : 002B22E05. Création : 17/04/1998.