Familial aggregation of gastroesophageal reflux in patients with Barrett's esophagus and esophageal adenocarcinoma.
Background & Aims
Barrett's esophagus and adenocarcinoma are complications of gastroesophageal reflux disease.
The aim of this study was to look for evidence of a familial predisposition to reflux.
Index patients with adenocarcinoma (n=27), Barrett's esophagus (n=40), and reflux esophagitis (n=55) were recruited from tertiary care and community populations.
Parents and siblings of patients (n=243) and their spouses'relatives (n=230) completed reflux symptom questionnaires (response rate, 86%). Results : Reflux symptoms were significantly more prevalent among parents and siblings of patients with adenocarcinoma (43% vs. 23%) and Barrett's esophagus (46% vs. 27%) than spouse control relatives.
No significant difference was found for the reflux esophagitis group (33% vs. 29%). Reflux was more prevalent in siblings than spouses of patients with Barrett's esophagus (41% vs. 12%) and adenocarcinoma (40% vs. 6%), a difference that was not found with reflux esophagitis (24% vs. 32%). Reflux was associated with obesity, 41% vs. 28% in the nonobese ; smoking, 45% vs. 31% in nonsmokers ; and men, 39% vs. 27% in women.
There may be a genetic predisposition to the development of reflux in families of patients with Barrett's esophagus and esophageal adenocarcinoma.
For uncomplicated reflux esophagitis, environmental factors appear more important.
Mots-clés Pascal : Reflux gastrooesophagien, Dépistage, Prédisposition, Oesophage Barrett, Adénocarcinome, Facteur prédictif, Expression génique, Enquête opinion, Milieu familial, Homme, Appareil digestif pathologie, Oesophage pathologie, Immunopathologie, Déterminisme génétique
Mots-clés Pascal anglais : Gastroesophageal reflux, Medical screening, Predisposition, Barrett esophagus, Adenocarcinoma, Predictive factor, Gene expression, Opinion inquiry, Family environment, Human, Digestive diseases, Esophageal disease, Immunopathology, Genetic determinism
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0002120
Code Inist : 002B13A03. Création : 17/04/1998.