A panel of immunological parameters has been examined in a group of dry-cleaning workers (n=21) and in a control group of administrators (n=16) from the same plant.
The results were also compared to long-term laboratory reference values (LR3) (n=14 - 311).
External exposure to tetrachloroethylene (PER) was represented by TWA (8 h) values In the range 11 - 752 mg PER/m. Biological monitoring showed an amount from 9 to 344 mg PER/m in exhaled air by the end of workshift. 1. The exposed dry-cleaning workers compared to the controls from the plant had statistically significant changes in metabolic activity of phagocytes, alpha2-macroglobulin, C3 and C4 complement component, salivary secretory IgA, and blastic transformation test.
Most of the values were within the range of normal values. 2. The exposed dry-cleaning workers had several abnormal immune parameters compared to the long-term laboratory values (LRV) especially in the alpha2-macroglobulin, C3 and percentage of T-lymphocytes.
Most of the changes, even those that were statistically significant, were still within the range of normal values, but they might be classified as trends or shifts away from normal (spontaneous blastic transformation, absolute number of phagocyting cells, coeruloplasmin, circulating immunocomplexes, serum lysozyme). 3. The non-exposed controls from the same plant showed both quantitative and qualitative differences when compared to the LRV. (...)
Mots-clés Pascal : Ethylène(tétrachloro), Solvant organique, Nettoyage, Surveillance biologique, Immunité humorale, Immunité cellulaire, Exploration immunologique, Homme, Toxicité, Réponse immune, Médecine travail, Exposition professionnelle, Nettoyage à sec
Mots-clés Pascal anglais : Ethylene(tetrachloro), Organic solvent, Cleaning, Biological monitoring, Humoral immunity, Cellular immunity, Immunological investigation, Human, Toxicity, Immune response, Occupational medicine, Occupational exposure
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0000590
Code Inist : 002B03L04. Création : 17/04/1998.