Sensitivity of olfaction (smell) and chemesthesis (irritation) was evaluated for 2-propanone (acetone) and 1-butanol in acetone-exposed workers (AEW ; N=32) during a workday and unexposed subjects (muES ; N=32).
Irritation sensitivity was assessed using a method that relies on the ability of individuals to localize irritants on the body.
When a volatile compound is inhaled into one nostril and air into the other, the stimulated side can be determined (lateralized) only after the concentration reaches a level that stimulates the trigeminal nerve (irritation) ; compounds stimulating olfaction alone cannot be lateralized.
Intranasal lateralization thresholds offer an objective measure of sensory irritation elicited by volatile compounds.
Test results indicated that neither olfactory nor lateralization thresholds for butanol differed between AEW and muES.
Olfactory thresholds to acetone in AEW (855 ppm) were elevated relative to those of muES (41 ppm), as were lateralization thresholds (36,669 ppm and 15,758 ppm, respectively).
Within AEW, level of occupational exposure was not correlated with thresholds.
Other measures revealed that muES used more irritation descriptors than did AEW on trials where the acetone concentration was below the lateralization threshold.
This is noteworthy because muES received lower concentrations of acetone to evaluate than did AEW. (...)
Mots-clés Pascal : Acétone, Solvant organique, Exposition professionnelle, Médecine travail, Toxicité, Homme, Irritation, Olfaction, Butanol, Composé organique volatil, Odeur, Voie respiratoire supérieure, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Acetone, Organic solvent, Occupational exposure, Occupational medicine, Toxicity, Human, Irritation, Olfaction, Butanol, Volatile organic compound, Odor, Upper respiratory tract, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 98-0000418
Code Inist : 002B03L04. Création : 17/04/1998.