Severe transient hy-pothyroxinemia in premature infants is associated with cerebral palsy and mental retardation ; this study assessed its prevalence in very premature infants.
Congenital hypothy-roidism screening programs in three states provided thyroxine values for 919 newborn infants younger than 29 weeks who were enrolled in a multicenter study.
Thyroxine values were lower than 4.0 mug/dL in 21% of survivors and increased each week by 0.6 mug/dL (95% confidence inter-val [CI]=0.4,0.7).
At tests done 1 to 2 days after birth, levels were 2.5 mug/dL higher (95% CI=1.8,3.3) than at tests done at 8 to 14 days.
In New York, levels were 1.0 mug/dL higher (95% CI=0.3,1.6) than else-where.
The levels of infants who died were 1.3 mug/dL lower (95% CI=0.6. 2.0) than those of survivors.
Severe transient hypothyroxinemia is common in very premature infants and deserves fur-ther study.
Mots-clés Pascal : Prématurité, Nouveau né, Homme, Taux, Thyroxine, Hormone thyroïdienne, Hormone aminoacide dérivé, Dépistage, Epidémiologie, Etats Unis, Amérique du Nord, Amérique, Gestation pathologie, Nouveau né pathologie
Mots-clés Pascal anglais : Prematurity, Newborn, Human, Rate, Thyroxine, Thyroid hormone, Aminoacid derivative hormone, Medical screening, Epidemiology, United States, North America, America, Pregnancy disorders, Newborn diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0551692
Code Inist : 002B20F02. Création : 24/03/1998.