Comparison of organochlorine pesticide and polychlorinated biphenyl residues in human breast adipose tissue and serum.
The presence of organochlorine pesticides, such as p, p'-DDT[2,2-bis (p-chlorophenyl) - 1,1,1-trichloroethane], and of polychlorinated biphenyls (PCBs) in human serum and adipose tissue has been reported in many studies over the last four decades.
Recently, debate has heightened concerning the link of these compounds to breast cancer.
To clarify and resolve this issue, accurate analytical residue data must be obtained.
Separation of the organochlorine pesticides from the PCBs in breast tissue is critical to obtaining valid residue data.
Based on methods refined in the Analytical Laboratory at Colorado State University, accurate residue levels were established for nine individual PCB congeners and eight organochlorine pesticides.
The breast adipose tissue method used was a modification of the Mills et al. and de Faubert Maunder et al. methods.
The serum method employed was a modification of the Burse et al. method.
Both breast adipose tissue and serum from 36 women were analyzed, and correlations of the residues from the two substrates were evaluated.
Serum concentrations of p, p'-DDE, the primary metabolite of p, p'-DDT, were correlated (a=05) with the concentrations of p, p'-DDE in human breast adipose tissue (r=808).
Serum concentrations of the PCB congener BZ 153 were also significantly correlated to the human breast adipose tissue concentrations of BZ 153 (r=377). (...)
Mots-clés Pascal : Accumulation biologique, Pesticide, Organochloré, DDT, Insecticide, Polluant, Hydrocarbure chloré, Biphényle(polychloro), Tissu adipeux, Glande mammaire, Sérum, Sang, Liquide biologique, Femme, Homme, Surveillance biologique, Connecticut, Etats Unis, Amérique du Nord, Amérique
Mots-clés Pascal anglais : Biological accumulation, Pesticides, Organochlorine compounds, DDT, Insecticide, Pollutant, Chlorocarbon, Polychlorobiphenyl, Adipose tissue, Mammary gland, Serum, Blood, Biological fluid, Woman, Human, Biological monitoring, Connecticut, United States, North America, America
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0548829
Code Inist : 002B03G. Création : 24/03/1998.