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  1. Identification of multiple sclerosis-associated genes.

    Article - En anglais

    Multiple sclerosis (MS) is a complex genetic trait.

    Analyses to identify genetic variants that increase susceptibility to MS have primarily focused on candidate genes, either in family linkage investigations or in association (linkage disequilibrium) studies in sporadic cases and control subjects.

    Most of the candidate genes considered to date either influence immune function or encode structural myelin proteins.

    Recently, three preliminary whole genomic surveys were completed, and they reveal multiple loci of possible genetic linkage that are worthy of further study.

    No convincing evidence for a single strong locus has emerged from analysis of the three studies.

    Linkage promises to focus the future choice of candidate genes for further investigation.

    Mots-clés Pascal : Sclérose en plaque, Epidémiologie, Diagnostic, Expression génique, Etude comparative, Enquête publique, Immunohistochimie, Etiopathogénie, Article synthèse, Homme, Etats Unis, Amérique du Nord, Amérique, Système nerveux pathologie, Système nerveux central pathologie, Maladie inflammatoire, Déterminisme génétique, Immunopathologie, Anatomopathologie, Organisation santé

    Mots-clés Pascal anglais : Multiple sclerosis, Epidemiology, Diagnosis, Gene expression, Comparative study, Public inquiry, Immunohistochemistry, Etiopathogenesis, Review, Human, United States, North America, America, Nervous system diseases, Central nervous system disease, Inflammatory disease, Genetic inheritance, Immunopathology, Pathology, Public health organization

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0547146

    Code Inist : 002B17F. Création : 24/03/1998.