Evidence of Toscana virus infections without central nervous system involvement : A serological study.
In central Italy, acute lymphocytic meningitis and meningoencephalitis due to a Phlebotomus transmitted virus (Phlebovirus Toscana, TOSv) occurring throughout the summer are frequently observed.
Several serum specimens of patients hospitalized with a clinical picture of viral meningitis/meningoencephalitis showed anti TOS-IgG reactivity suggestive of a previous infection occurring at an unknown time in the past.
This observation led us to design a serological investigation of 83 household contacts of 46 summertime CNS infection patients (index cases) with the purpose of evaluating the percentage of both IgG and IgM in seropositive healthy individuals, living, like the index cases, in areas at high risk of phlebotomine sandfly bites.
The serological study was carried out using an ELISA method :
22% of the sera showed a reactivity for anti-TOS IgG antibodies and 6% resulted IgG/IgM positive ;
none of them reported having had any symptoms of CNS involvement ;
the distribution of seropositive cases was similar in contacts of both TOS-confirmed and TOS-negative cases. (...)
Mots-clés Pascal : Phlebovirus, Bunyaviridae, Virus, Virose, Infection, Séropositivité, Phlebotomus, Psychodidae, Diptera, Insecta, Arthropoda, Invertebrata, Vecteur, Asymptomatique, Transmission, Milieu familial, Diagnostic, Italie, Europe, Méningite, Système nerveux central pathologie, Système nerveux pathologie
Mots-clés Pascal anglais : Phlebovirus, Bunyaviridae, Virus, Viral disease, Infection, Seropositivity, Phlebotomus, Psychodidae, Diptera, Insecta, Arthropoda, Invertebrata, Vector, Asymptomatic, Transmission, Family environment, Diagnosis, Italy, Europe, Meningitis, Central nervous system disease, Nervous system diseases
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0546228
Code Inist : 002B05C02A. Création : 24/03/1998.