Zinc oxide inhalation causes metal fume fever, a flu-like syndrome common among welders.
Proinflammatory pulmonary cytokines play a role in mediating this occupational illness.
The goal of this investigation was to characterize early pulmonary cytokine responses after experimental human exposure to inhaled purified zinc oxide fume.
We quantified bronchoalveolar lavage (BAL) cytokine concentrations in 15 healthy volunteers 3 hr after inhalation of zinc oxide fume.
We compared postexposure cytokine responses with postsham exposure responses in the same 15 subjects.
We also compared cytokine responses with those of 14 « late follow-up » subjects previously studied by BAL 20 hr after zinc oxide fume exposure.
Zinc oxide exposure was a statistically significant, dose-dependent predictor of increases in BAL TNF (mean exposure-sham difference ± SE=9.5 ± 3.6 pg/mL, P=0.02), IL-6 (mean exposure-sham difference ± SE=5.5 ± 1.8 pg/mL, P=0.009), and IL-8 (mean exposure-sham difference ± SE=64.1 ± 23.9 pg/mL, P=0.02).
The TNF response was significantly greater at 3 hr follow-up compared with 20 hr follow-up, after adjusting for smoking status, zinc dose, and BAL macrophages (P=0.004).
Our findings provide evidence for a pulmonary inflammatory response 3 hr after inhalation of zinc oxide fume characterized by dose-dependent increases in BAL proinflammatory cytokine concentrations.
These data indicate that TNF plays an important initial role in mediating metal fume fever.
Mots-clés Pascal : Zinc Oxyde, Toxicité, Soudage, Fièvre vapeur métallique, Exposition professionnelle, Médecine travail, Homme, Mécanisme action, Cytokine, Poumon, Facteur nécrose tumorale, Lavage bronchoalvéolaire, Inhalation, Appareil respiratoire pathologie
Mots-clés Pascal anglais : Zinc Oxides, Toxicity, Welding, Metal fumes fever, Occupational exposure, Occupational medicine, Human, Mechanism of action, Cytokine, Lung, Tumor necrosis factor, Bronchoalveolar lavage, Inhalation, Respiratory disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0543688
Code Inist : 002B03L05. Création : 24/03/1998.