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  1. Price of adaptation : Allostatic load and its health consequences : MacArthur studies of successful aging.

    Article - En anglais


    Exponential growth in the population of older adults presents clinicians with special concerns about factors affecting risks for declines in cognitive and physical functioning.


    To examine the hypothesis that risks for such declines and for disease outcomes, such as cardiovascular disease, are related to differences in allostatic load, the cumulative physiologic toll exacted on the body over time by efforts to adapt to life experiences.

    To present an operational definition of allostatic load, along with preliminary evidence of its predictive validity in relation to salient outcomes of aging.


    Data from a longitudinal, community-based study of successful aging were used to develop a measure of allostatic load based on 10 parameters reflecting levels of physiologic activity across a range of important regulatory systems.

    Allostatic load is the sum of the number of parameters for which the subject was rated in the highest-risk quartile.


    Higher allostatic load scores were associated with poorer cognitive and physical functioning and predicted larger decrements in cognitive and physical functioning as well as being associated with an increased risk for the incidence of cardiovascular disease, independent of sociodemographic and health status risk factors. (...)

    Mots-clés Pascal : Vieillissement naturel, Evaluation, Evolution, Psychomotricité, Effet biologique, Age, Activité humaine, Morbidité, Résultat, Vieillard, Homme, Gériatrie

    Mots-clés Pascal anglais : Natural ageing, Evaluation, Evolution, Psychomotricity, Biological effect, Age, Human activity, Morbidity, Result, Elderly, Human, Geriatrics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0543307

    Code Inist : 002B30A01A2. Création : 24/03/1998.