logo BDSP

Base documentaire


Votre avis nous intéresse

Le réseau BDSP met en oeuvre un projet d'innovation et d'amélioration de ses services, dans le souci constant de proposer des contenus de qualité adaptés aux besoins des utilisateurs.

Identifier de nouvelles sources de financements est la condition nécessaire pour assurer la poursuite et la pérennité de cet outil unique qu'est la BDSP, tout en le faisant évoluer.

Pour définir un nouveau modèle économique, nous avons besoin de votre avis : merci de répondre à notre enquête (temps estimé : 5 minutes).

Participer maintenant
Participer plus tard J'ai déjà participé

  1. Price of adaptation : Allostatic load and its health consequences : MacArthur studies of successful aging.

    Article - En anglais

    Background 

    Exponential growth in the population of older adults presents clinicians with special concerns about factors affecting risks for declines in cognitive and physical functioning.

    Objectives 

    To examine the hypothesis that risks for such declines and for disease outcomes, such as cardiovascular disease, are related to differences in allostatic load, the cumulative physiologic toll exacted on the body over time by efforts to adapt to life experiences.

    To present an operational definition of allostatic load, along with preliminary evidence of its predictive validity in relation to salient outcomes of aging.

    Methods 

    Data from a longitudinal, community-based study of successful aging were used to develop a measure of allostatic load based on 10 parameters reflecting levels of physiologic activity across a range of important regulatory systems.

    Allostatic load is the sum of the number of parameters for which the subject was rated in the highest-risk quartile.

    Results 

    Higher allostatic load scores were associated with poorer cognitive and physical functioning and predicted larger decrements in cognitive and physical functioning as well as being associated with an increased risk for the incidence of cardiovascular disease, independent of sociodemographic and health status risk factors. (...)

    Mots-clés Pascal : Vieillissement naturel, Evaluation, Evolution, Psychomotricité, Effet biologique, Age, Activité humaine, Morbidité, Résultat, Vieillard, Homme, Gériatrie

    Mots-clés Pascal anglais : Natural ageing, Evaluation, Evolution, Psychomotricity, Biological effect, Age, Human activity, Morbidity, Result, Elderly, Human, Geriatrics

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0543307

    Code Inist : 002B30A01A2. Création : 24/03/1998.