Backgrounds Most previous studies of estrogen replacement therapy (ERT) and mortality have focused on younger women.
Recently, it has been suggested that the effect of ERT on mortality may represent a « healthy-user » effect, ie, those with healthier lifestyles having a greater likelihood of receiving ERT.
Nine thousand seven hundred four women, 65 years or older, participated ; 1258 (14.1%) reported current use of ERT for at least 1 year at entry.
During an average follow-up of 6.0 years, 1054 women (11.8%) died.
After adjusting for multiple variables, mortality rate was lower among current (relative risk [RR], 0.69 ; 95% confidence interval [CI], 0.54-0.87) and past users (RR, 0.79 ; 95% CI, 0.66-0.95), mainly due to reductions in deaths due to cardiovascular disease.
The protective effect of ERT was greatest among women younger than 75 years (RR, 0.55 ; 95% CI, 0.40-0.76) compared with women from 75 to 84 years of age (RR, 0.93 ; 95% CI, 0.62-1.41) and 85 years or older (RR, 1.33 ; 95% CI, 0.43-4.12).
The RR for overall mortality was 0.95 (95% CI, 0.68-1.32) among short-term users (1-9 years) compared with 0.55 (95% Cl, 0.40-0.75) among long-term users (= 10 years).
Deaths considered unrelated to ERT tended also to be reduced in current users younger than 75 years (RR, 0.72 ; 95% CI, 0.49-1.06) and current long-term users (RR, 0.75 ; 95% CI, 0.51-1.10). (...)
Mots-clés Pascal : Opothérapie, Oestrogène, Effet biologique, Morbidité, Cardiopathie coronaire, Incidence, Etude statistique, Homme, Femelle, Appareil génital femelle, Appareil circulatoire pathologie
Mots-clés Pascal anglais : Opotherapy, Estrogen, Biological effect, Morbidity, Coronary heart disease, Incidence, Statistical study, Human, Female, Female genital system, Cardiovascular disease
Notice produite par :
Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0543297
Code Inist : 002B02O. Création : 24/03/1998.