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  1. Impact of age on the severity, course, and complications of alcohol withdrawal.

    Article - En anglais


    Early identification of alcohol-dependent patients at increased risk for severe or complicated alcohol withdrawal would improve triage and treatment.

    However, the role of age in predicting alcohol withdrawal outcomes has not been well studied.


    To assess the impact of age on the severity, course, and complications of alcohol withdrawal.


    We performed a retrospective cohort study of 284 inpatients admitted for alcohol withdrawal between September 1992 and August 1994.

    Outcomes included alcohol withdrawal severity measured by the revised Clinical Institute Withdrawal Assessment for Alcohol scale, quantity and duration of benzodiazepine therapy, and complications during withdrawal.


    Initial and maximal withdrawal severity scores, amount of benzodiazepine administered, and duration of benzodiazepine treatment for elevated withdrawal severity scores did not change significantly with age.

    However, patients aged 60 years and older had increased risk for delirium (adjusted odds ratio [OR], 4.7 ; 95% confidence interval[CI], 1.5-15.0 ; P=008), falls (OR, 3.1 ; 95% CI, 0.9-11.2 ; P=08), and transient dependency in 2 or more activities of daily living (OR, 5.8 ; 95% Cl, 2.9-11.7 ; P<. 001).

    As age increased, there were significant increases in length of stay (P<. 001) and frequency of discharge to an extended care facility (P<. 001). (...)

    Mots-clés Pascal : Alcoolisme, Effet biologique, Abstinence, Arrêt exposition, Relation, Age, Indice gravité, Complication, Chimiothérapie, Benzodiazépine dérivé, Résultat, Homme, Toxicomanie, Système nerveux pathologie, Système nerveux central pathologie, Trouble neurologique

    Mots-clés Pascal anglais : Alcoholism, Biological effect, Abstinence, Exposure stopping, Relation, Age, Severity score, Complication, Chemotherapy, Benzodiazepine derivatives, Result, Human, Drug addiction, Nervous system diseases, Central nervous system disease, Neurological disorder

    Logo du centre Notice produite par :
    Inist-CNRS - Institut de l'Information Scientifique et Technique

    Cote : 97-0542816

    Code Inist : 002B03F. Création : 24/03/1998.