A neurobehavioural study of long-term occupational inorganic lead exposure.
Copyright (c) 1997 Elsevier Science B.V. All rights reserved.
A group of 38 male workers at a secondary smelter (period of employment 2-35 years ; median 10 years) was divided into two subgroups depending on bone-lead concentration, arranged as 19 matched pairs according to age, education and job level.
The median concentrations for finger-bone lead (Bone-Pb) were 16 vs. 32 gmg/g ; for current blood-lead (B-Pb), 1.6 vs. 1.8 mumol/l ; for retrospective peak blood-lead (Peak-Pb), 2.7 vs. 3.0 mumol/l ; and for a retrospective cumulative blood lead index (CBLI), 143 vs. 233 mumol/lxmonths.
Nineteen unexposed male workers from a nearby mechanical plant served as controls, using the same matching algorithm.
The triplets were examined with a standardised neuropsychological test battery, and four questionnaires for self-rating of symptoms and activity/stress level related to work environment.
No sign of behavioural deterioration was observed in the exposed groups, either in objective cognitive tests or in subjective symptom/mood self-rating scales.
Despite the limited sample size, the statistical power was sufficient to conclude that a concealed lead-associated effect was unlikely.
Covariations between behavioural measures and lead exposure in dices were generally low and non-significant, as a whole not exceeding a random level.
No confounding or effect-modifying factor was detected that could explain the results as a type II error.
To conclude, a current B-Pb of 1. (...)
Mots-clés Pascal : Plomb, Métal lourd, Toxicité, Exposition professionnelle, Médecine travail, Homme, Système nerveux pathologie, Fonderie, Industrie métallurgique, Test neuropsychologique, Système nerveux central, Comportement, Suède, Europe, Chronique
Mots-clés Pascal anglais : Lead, Heavy metal, Toxicity, Occupational exposure, Occupational medicine, Human, Nervous system diseases, Foundry, Metallurgical industry, Neuropsychological test, Central nervous system, Behavior, Sweden, Europe, Chronic
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Inist-CNRS - Institut de l'Information Scientifique et Technique
Cote : 97-0542618
Code Inist : 002B03L05. Création : 24/03/1998.